Immunology of Vaccine Adjuvants

C.M.S. Ribeiro, V.E.J.C. Schijns

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

28 Citations (Scopus)


In recent times vaccine adjuvants, or immunopotentiators, received abundant attention in the media as critical ingredients of current and future vaccines. Indeed, vaccine adjuvants are recognized to make the difference between competing vaccines based on identical antigens. Moreover, it is recognized that vaccines designed for certain indications require a matching combination of selected antigen(s) together with a critical immunopotentiator that selectively drives the required immune pathway with minimal adverse reactions. Recently, the mechanistic actions of some immunopotentiators have become clearer as a result of research focused on innate immunity receptors. These insights enable more rational adjuvant and vaccine design, which, ideally, is based on predictable immunophenotypes following vaccination. This chapter addresses immunopotentiators, classed according to their (presumed) mechanisms of action. They are categorized functionally in two major groups as facilitators of signal 1 and/or signal 2. The mode(s) of action of some well-known adjuvant prototypes is discussed in the context of this classification
Original languageEnglish
Title of host publicationVaccine Adjuvants
EditorsG. Davies
Place of PublicationTotowa
PublisherHumana Press
Number of pages14
ISBN (Electronic)9781607615859
ISBN (Print)9781607615842
Publication statusPublished - 2010

Publication series

NameMethods in molecular biology
PublisherSpringer Verlag
ISSN (Print)1064-3745


Dive into the research topics of 'Immunology of Vaccine Adjuvants'. Together they form a unique fingerprint.

Cite this