Immune modulation by cow’s milk components

Implications for respiratory health

Ó.IJ. Perdijk

Research output: Thesisinternal PhD, WU

Abstract

In a growing world population in which chronic inflammatory diseases are on the rise and allergies and asthma affect 30-40% of the population, there is a pressing need to understand underlying mechanisms to develop successful preventive strategies for these diseases. Raw cow’s milk consumption in early life has been associated in epidemiological studies with a significant decrease in the prevalence of allergies and asthma. In this thesis we investigated the effect of components present in raw cow’s milk on maintenance of mucosal immune functioning in the gut and discussed their implications for respiratory health. We thereby give novel insights into the underlying mechanisms by which raw cow’s milk components display their immunomodulatory capacity and may contribute to regulation of mucosal immune responses. Future studies should further investigate the effects of these components in in vivo allergy and respiratory infection models, to better understand the link between diet and respiratory health.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • van Neerven, Joost, Promotor
  • Savelkoul, Huub, Promotor
  • Brugman, Sylvia, Co-promotor
Award date12 Oct 2018
Place of PublicationWageningen
Publisher
Print ISBNs9789463434911
DOIs
Publication statusPublished - 2018

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Hypersensitivity
Milk
Health
Asthma
Mucosal Immunity
Respiratory Tract Infections
Population
Epidemiologic Studies
Chronic Disease
Maintenance
Diet

Cite this

Perdijk, Ó.IJ.. / Immune modulation by cow’s milk components : Implications for respiratory health. Wageningen : Wageningen University, 2018. 268 p.
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abstract = "In a growing world population in which chronic inflammatory diseases are on the rise and allergies and asthma affect 30-40{\%} of the population, there is a pressing need to understand underlying mechanisms to develop successful preventive strategies for these diseases. Raw cow’s milk consumption in early life has been associated in epidemiological studies with a significant decrease in the prevalence of allergies and asthma. In this thesis we investigated the effect of components present in raw cow’s milk on maintenance of mucosal immune functioning in the gut and discussed their implications for respiratory health. We thereby give novel insights into the underlying mechanisms by which raw cow’s milk components display their immunomodulatory capacity and may contribute to regulation of mucosal immune responses. Future studies should further investigate the effects of these components in in vivo allergy and respiratory infection models, to better understand the link between diet and respiratory health.",
author = "Ó.IJ. Perdijk",
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Perdijk, OIJ 2018, 'Immune modulation by cow’s milk components: Implications for respiratory health', Doctor of Philosophy, Wageningen University, Wageningen. https://doi.org/10.18174/457213

Immune modulation by cow’s milk components : Implications for respiratory health. / Perdijk, Ó.IJ.

Wageningen : Wageningen University, 2018. 268 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Immune modulation by cow’s milk components

T2 - Implications for respiratory health

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PY - 2018

Y1 - 2018

N2 - In a growing world population in which chronic inflammatory diseases are on the rise and allergies and asthma affect 30-40% of the population, there is a pressing need to understand underlying mechanisms to develop successful preventive strategies for these diseases. Raw cow’s milk consumption in early life has been associated in epidemiological studies with a significant decrease in the prevalence of allergies and asthma. In this thesis we investigated the effect of components present in raw cow’s milk on maintenance of mucosal immune functioning in the gut and discussed their implications for respiratory health. We thereby give novel insights into the underlying mechanisms by which raw cow’s milk components display their immunomodulatory capacity and may contribute to regulation of mucosal immune responses. Future studies should further investigate the effects of these components in in vivo allergy and respiratory infection models, to better understand the link between diet and respiratory health.

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