Illegal treatment of barrows with nandrolone ester: effect on growth, histology and residue levels in urine and hair

M.J. Groot, J.J.P. Lasaroms, E.O. van Bennekom, T. Meijer, E. Vinyeta, J.D. van der Klis, M.W.F. Nielen

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Abstract

The effect of 17ß-19-nortestosterone (17ßNT) treatment of barrows on residue levels and growth was evaluated. Five barrows were treated three times during the fattening period with 17ßNT phenylpropionate (Nandrosol, nandrolone phenylpropionate 50¿mg/ml,1¿mg/kg body weight). Another five barrows were untreated and five boars (untreated) were kept as positive control. Boars and treated barrows showed a 13 and 9% improvement in growth compared to untreated barrows, with mean final body weights of 121.6, 117.8 and 109.0¿kg, respectively. The bulbourethral glands of the treated barrows were three times heavier than untreated barrows. The histology of the prostate and bulbourethral gland of the treated barrows was comparable to the boars, whereas the control barrows showed atrophic glands. Levels of 17ßNT ester in hair from treated barrows were high, whereas boars and untreated barrows did not show levels above LLQ. It is concluded that analysis of hair can detect illegal treatment with 17ßNT ester in barrows. The size of the bulbourethral gland can also be used for screening in the slaughterhouse.
Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalFood Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Volume29
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint

nandrolone
Nandrolone
Histology
barrows
Bulbourethral Glands
histology
hairs
Esters
urine
esters
Urine
Growth
bulbourethral gland
boars
Phenylpropionates
Body Weight
phenylpropionates
Therapeutics
Abattoirs
Prostate

Keywords

  • mass-spectrometry
  • testosterone
  • castration
  • steroids
  • pigs
  • 19-nortestosterone
  • metabolism
  • estradiol
  • carcass
  • boars

Cite this

@article{fd2727afe29d4a4e879c1a72c5da050c,
title = "Illegal treatment of barrows with nandrolone ester: effect on growth, histology and residue levels in urine and hair",
abstract = "The effect of 17{\ss}-19-nortestosterone (17{\ss}NT) treatment of barrows on residue levels and growth was evaluated. Five barrows were treated three times during the fattening period with 17{\ss}NT phenylpropionate (Nandrosol, nandrolone phenylpropionate 50¿mg/ml,1¿mg/kg body weight). Another five barrows were untreated and five boars (untreated) were kept as positive control. Boars and treated barrows showed a 13 and 9{\%} improvement in growth compared to untreated barrows, with mean final body weights of 121.6, 117.8 and 109.0¿kg, respectively. The bulbourethral glands of the treated barrows were three times heavier than untreated barrows. The histology of the prostate and bulbourethral gland of the treated barrows was comparable to the boars, whereas the control barrows showed atrophic glands. Levels of 17{\ss}NT ester in hair from treated barrows were high, whereas boars and untreated barrows did not show levels above LLQ. It is concluded that analysis of hair can detect illegal treatment with 17{\ss}NT ester in barrows. The size of the bulbourethral gland can also be used for screening in the slaughterhouse.",
keywords = "mass-spectrometry, testosterone, castration, steroids, pigs, 19-nortestosterone, metabolism, estradiol, carcass, boars",
author = "M.J. Groot and J.J.P. Lasaroms and {van Bennekom}, E.O. and T. Meijer and E. Vinyeta and {van der Klis}, J.D. and M.W.F. Nielen",
year = "2012",
doi = "10.1080/19440049.2011.647097",
language = "English",
volume = "29",
pages = "727--735",
journal = "Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment",
issn = "1944-0049",
publisher = "Taylor & Francis",
number = "5",

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TY - JOUR

T1 - Illegal treatment of barrows with nandrolone ester: effect on growth, histology and residue levels in urine and hair

AU - Groot, M.J.

AU - Lasaroms, J.J.P.

AU - van Bennekom, E.O.

AU - Meijer, T.

AU - Vinyeta, E.

AU - van der Klis, J.D.

AU - Nielen, M.W.F.

PY - 2012

Y1 - 2012

N2 - The effect of 17ß-19-nortestosterone (17ßNT) treatment of barrows on residue levels and growth was evaluated. Five barrows were treated three times during the fattening period with 17ßNT phenylpropionate (Nandrosol, nandrolone phenylpropionate 50¿mg/ml,1¿mg/kg body weight). Another five barrows were untreated and five boars (untreated) were kept as positive control. Boars and treated barrows showed a 13 and 9% improvement in growth compared to untreated barrows, with mean final body weights of 121.6, 117.8 and 109.0¿kg, respectively. The bulbourethral glands of the treated barrows were three times heavier than untreated barrows. The histology of the prostate and bulbourethral gland of the treated barrows was comparable to the boars, whereas the control barrows showed atrophic glands. Levels of 17ßNT ester in hair from treated barrows were high, whereas boars and untreated barrows did not show levels above LLQ. It is concluded that analysis of hair can detect illegal treatment with 17ßNT ester in barrows. The size of the bulbourethral gland can also be used for screening in the slaughterhouse.

AB - The effect of 17ß-19-nortestosterone (17ßNT) treatment of barrows on residue levels and growth was evaluated. Five barrows were treated three times during the fattening period with 17ßNT phenylpropionate (Nandrosol, nandrolone phenylpropionate 50¿mg/ml,1¿mg/kg body weight). Another five barrows were untreated and five boars (untreated) were kept as positive control. Boars and treated barrows showed a 13 and 9% improvement in growth compared to untreated barrows, with mean final body weights of 121.6, 117.8 and 109.0¿kg, respectively. The bulbourethral glands of the treated barrows were three times heavier than untreated barrows. The histology of the prostate and bulbourethral gland of the treated barrows was comparable to the boars, whereas the control barrows showed atrophic glands. Levels of 17ßNT ester in hair from treated barrows were high, whereas boars and untreated barrows did not show levels above LLQ. It is concluded that analysis of hair can detect illegal treatment with 17ßNT ester in barrows. The size of the bulbourethral gland can also be used for screening in the slaughterhouse.

KW - mass-spectrometry

KW - testosterone

KW - castration

KW - steroids

KW - pigs

KW - 19-nortestosterone

KW - metabolism

KW - estradiol

KW - carcass

KW - boars

U2 - 10.1080/19440049.2011.647097

DO - 10.1080/19440049.2011.647097

M3 - Article

VL - 29

SP - 727

EP - 735

JO - Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment

JF - Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment

SN - 1944-0049

IS - 5

ER -