Illegal treatment of barrows with nandrolone ester: effect on growth, histology and residue levels in urine and hair

M.J. Groot, J.J.P. Lasaroms, E.O. van Bennekom, T. Meijer, E. Vinyeta, J.D. van der Klis, M.W.F. Nielen

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The effect of 17ß-19-nortestosterone (17ßNT) treatment of barrows on residue levels and growth was evaluated. Five barrows were treated three times during the fattening period with 17ßNT phenylpropionate (Nandrosol, nandrolone phenylpropionate 50¿mg/ml,1¿mg/kg body weight). Another five barrows were untreated and five boars (untreated) were kept as positive control. Boars and treated barrows showed a 13 and 9% improvement in growth compared to untreated barrows, with mean final body weights of 121.6, 117.8 and 109.0¿kg, respectively. The bulbourethral glands of the treated barrows were three times heavier than untreated barrows. The histology of the prostate and bulbourethral gland of the treated barrows was comparable to the boars, whereas the control barrows showed atrophic glands. Levels of 17ßNT ester in hair from treated barrows were high, whereas boars and untreated barrows did not show levels above LLQ. It is concluded that analysis of hair can detect illegal treatment with 17ßNT ester in barrows. The size of the bulbourethral gland can also be used for screening in the slaughterhouse.
Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalFood Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Volume29
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • mass-spectrometry
  • testosterone
  • castration
  • steroids
  • pigs
  • 19-nortestosterone
  • metabolism
  • estradiol
  • carcass
  • boars

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