IL-4 can correct defective IgE production in SJA/9 mice

H.F.J. Savelkoul, B.W.P. Seymour, L. Sullivan, R.L. Coffman

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31 Citations (Scopus)


SJA/9 mice are unable to produce significant serum IgE responses to either primary or secondary challenge with protein Ag or helminth parasites. Previous work has shown that this defect resides the T cell rather than with the B cells. These experiments test several possible explanations for the lack of IgE production in these mice. SJA/9 mice do not appear to overproduce IFN-gamma or any other antagonist of IL-4 function. Helminth parasite infection induces normal levels of IL-5- dependent eosinophilia, suggesting that there is not a complete absence of a Th2 response in these mice. The defect, however can be explained by a substantial reduction in IL-4 production in vivo and can be corrected by infusion with IL-4. The reason for this lack of IL-4 production is not yet clear and, paradoxically, SJA/9 T cells can be stimulated in vitro to produce IL-4 levels comparable to T cells from other strains.
Original languageEnglish
Pages (from-to)1801-1805
JournalThe Journal of Immunology
Issue number6
Publication statusPublished - 1991
Externally publishedYes

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