Identification of unknown residues : using bioassay directed fractionation, UPLC/TOFMS analysis and database searching

R.J.B. Peters, J.C.W. Rijk, J.E. Oosterink, A.W.J.M. Nijrolder, M.W.F. Nielen

    Research output: Book/ReportReportProfessional

    Abstract

    Nowadays a large number of compounds are determined in environmental and food samples. Biological tests are used to screen samples for large groups of compounds having a particular effect, but it is often difficult to identify a specific compound when a positive effect is observed. The identification of an unknown compound is a challenge for analytical chemistry in environmental analysis, food analysis, as well as in clinical and forensic toxicology. This study reports on the development of a procedure for the identification of unknown residues in samples suspected of containing illegal substances and samples showing bioactivity in bioassay - or microbiological screening assays. For testing purposes several samples were selected; a number of so-called "cold cases", historical samples that were suspected of containing illegal growth promoting substances, herbal mixtures and sport supplements.
    Original languageEnglish
    Place of PublicationWageningen
    PublisherRIKILT
    Number of pages47
    Publication statusPublished - 2009

    Publication series

    NameReport / RIKILT
    PublisherRikilt, Institute of Food Safety
    No.2009.013

    Keywords

    • residues
    • analytical methods
    • bioassays
    • liquid chromatography
    • mass spectrometry

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