Identification of TUB as a Novel Candidate Gene Influencing Body Weight in Humans

R. Shiri-Sverdlov, A. Custers, J.V. Vliet-Ostaptchouk, P.J.J. van Gorp, P.J. Lindsey, J.H.O. van Tilburg, S. Zhernakova, E.J.M. Feskens, D.L. van der A, M.E.T. Dollé, T.W. van Haeften, B.P.C. Koeleman, M.H. Hofker, C. Wijmenga

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19 Citations (Scopus)


Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based on mouse studies, we selected TUB as a functional candidate gene and performed association studies to determine whether this controls obesity. We analyzed the genotypes of 13 single nucleotide polymorphisms (SNPs) around TUB in 492 unrelated type 2 diabetic patients with known BMI values. One SNP (rs1528133) was found to have a significant effect on BMI (1.54 kg/m2, P = 0.006). This association was confirmed in a population enriched for type 2 diabetes, using 750 individuals who were not selected for type 2 diabetes. Two SNPs in linkage disequilibrium with rs1528133 and mapping to the 3' end of TUB, rs2272382, and rs2272383 also affected BMI by 1.3 kg/m2 (P = 0.016 and P = 0.010, respectively). Combined analysis confirmed this association (P = 0.005 and P = 0.002, respectively). Moreover, comparing 349 obese subjects (BMI >30 kg/m2) from the combined cohort with 289 normal subjects (BMI
Original languageEnglish
Pages (from-to)385-389
Issue number2
Publication statusPublished - 2006


  • recessive mutations
  • obesity
  • population
  • protein
  • mouse
  • tulp1
  • fat

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