Identification of Novel Regulators Associated With Early-Phase Osteoblast Differentiation

D.S. de Jong, B.L.T. Vaes, K.J. Dechering, A. Feijen, J.M.A. Hendriks, H.R.M.J. Wehrens, C.L. Mummery, E.J.J. van Zoelen, W. Olijve, W.T. Steegenga

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Abstract

Key regulatory components of the BMP-induced osteoblast differentiation cascade remain to be established. Microarray and subsequent expression analyses in mice identified two transcription factors, Hey1 and Tcf7, with in vitro and in vivo expression characteristics very similar to Cbfa1. Transfection studies suggest that Tcf7 modulates BMP2-induced osteoblast differentiation. This study contributes to a better definition of the onset of BMP-induced osteoblast differentiation.
Original languageEnglish
Pages (from-to)947-958
JournalJournal of Bone and Mineral Research
Volume19
Issue number6
DOIs
Publication statusPublished - 2004

Keywords

  • bone morphogenetic protein-2
  • growth-factor-beta
  • gene-expression
  • transcription factor
  • cell-differentiation
  • microarray analysis
  • smad proteins
  • i receptors
  • cbfa1
  • loop

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    de Jong, D. S., Vaes, B. L. T., Dechering, K. J., Feijen, A., Hendriks, J. M. A., Wehrens, H. R. M. J., Mummery, C. L., van Zoelen, E. J. J., Olijve, W., & Steegenga, W. T. (2004). Identification of Novel Regulators Associated With Early-Phase Osteoblast Differentiation. Journal of Bone and Mineral Research, 19(6), 947-958. https://doi.org/10.1359/JBMR.040216