Identification of new biomarkers for early natural TSE detection using a genome-wide approach

A. Bossers, F.L. Harders, L.J.M. van Keulen, F.G. van Zijderveld

    Research output: Book/ReportReportProfessional


    This research focuses on the genome-wide identification of new biomarkers (other than PrP) that might be useful to extend current TSE diagnostics especially in the preclinical phase. In addition this project might provide clues to better understand the TSE micro-pathogenesis. Specific aims: - generate a non-redundant sheep microarray from primary lymphoid tissues; − collect and preserve well documented material for RNA isolation from natural scrapie exposed or clean environments; − determine differential expressed genes between the collected samples and relate these to natural scrapie infection. These identified biomarkers might turn useful for the development of preclinical tests (at best on live animals) in the very early phase of natural scrapie infection. Such tests can support the control of scrapie in the field
    Original languageEnglish
    Place of PublicationUK
    Publication statusPublished - 2007

    Publication series

    NameProject final report to Medical Research Council


    • sheep farming
    • sheep
    • dna
    • biological techniques
    • animal diseases
    • sheep diseases
    • scrapie
    • genomes
    • microarrays
    • dna microarrays
    • biomarkers


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