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Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly affects survival and quality of life. A common denominator of many chronic diseases is an elevated inflammatory status, which is considered to play a pivotal role in the failure of food-intake regulating systems in the hypothalamus. In this review, we summarize findings on the role of hypothalamic inflammation on food intake regulation involving hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role of serotonin in the inability of these peptide based food-intake regulating systems to respond and adapt to changes in energy metabolism during chronic disease.
Dwarkasing, J. T., Marks, D. L., Witkamp, R. F., & van Norren, K. (2016). Hypothalamic inflammation and food intake regulation during chronic illness. Peptides, 77, 60-66. https://doi.org/10.1016/j.peptides.2015.06.011