Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

Wuyuan Zhang, Ming Ma, Mieke M.E. Huijbers, Georgy A. Filonenko, Evgeny A. Pidko, Morten van Schie, Sabrina de Boer, Bastien O. Burek, Jonathan Z. Bloh, Willem J.H. van Berkel, Wilson A. Smith, Frank Hollmann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)


A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.

Original languageEnglish
Pages (from-to)3116-3120
JournalJournal of the American Chemical Society
Issue number7
Publication statusPublished - 20 Feb 2019

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