Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

Wuyuan Zhang; Ming Ma; Mieke M.E. Huijbers; Georgy A. Filonenko; Evgeny A. Pidko; Morten van Schie; Sabrina de Boer; Bastien O. Burek; Jonathan Z. Bloh; Willem J.H. van Berkel; Wilson A. Smith; Frank Hollmann

doi:10.1021/jacs.8b12282

Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

Wuyuan Zhang, Ming Ma, Mieke M.E. Huijbers, Georgy A. Filonenko, Evgeny A. Pidko, Morten van Schie, Sabrina de Boer, Bastien O. Burek, Jonathan Z. Bloh, Willem J.H. van Berkel, Wilson A. Smith, Frank Hollmann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

129 Citations (Scopus)

Abstract

A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.

Original language	English
Pages (from-to)	3116-3120
Journal	Journal of the American Chemical Society
Volume	141
Issue number	7
DOIs	https://doi.org/10.1021/jacs.8b12282
Publication status	Published - 20 Feb 2019

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title = "Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids",

abstract = "A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.",

author = "Wuyuan Zhang and Ming Ma and Huijbers, {Mieke M.E.} and Filonenko, {Georgy A.} and Pidko, {Evgeny A.} and {van Schie}, Morten and {de Boer}, Sabrina and Burek, {Bastien O.} and Bloh, {Jonathan Z.} and {van Berkel}, {Willem J.H.} and Smith, {Wilson A.} and Frank Hollmann",

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doi = "10.1021/jacs.8b12282",

language = "English",

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TY - JOUR

T1 - Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

AU - Zhang, Wuyuan

AU - Ma, Ming

AU - Huijbers, Mieke M.E.

AU - Filonenko, Georgy A.

AU - Pidko, Evgeny A.

AU - van Schie, Morten

AU - de Boer, Sabrina

AU - Burek, Bastien O.

AU - Bloh, Jonathan Z.

AU - van Berkel, Willem J.H.

AU - Smith, Wilson A.

AU - Hollmann, Frank

PY - 2019/2/20

Y1 - 2019/2/20

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AB - A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.

U2 - 10.1021/jacs.8b12282

DO - 10.1021/jacs.8b12282

M3 - Article

C2 - 30673222

AN - SCOPUS:85061856663

SN - 0002-7863

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EP - 3120

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 7

ER -

Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

Abstract

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