Hydrioxylation of sesquiterpenes by enzymes from chicory (Cichorium intybus L.) roots

J.W. de Kraker, M. Schurink, M.C.R. Franssen, W.A. König, Æ. de Groot, H.J. Bouwmeester

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)


A microsomal enzyme preparation of chicory roots catalyses the hydroxylation of various sesquiterpene olefins in the presence of NADPH. Most of these hydroxylations take place at an isopropenyl or isopropylidene group. The number of products obtained from any of the substrates is confined to one or, in a few cases, two sesquiterpene alcohols. In addition, the conversion of ( )-valencene into nootkatone through -nootkatol was observed. The involvement of ( )-germacrene A hydroxylase (a cytochrome P450 enzyme) and other enzymes of sesquiterpene lactone biosynthesis in these reactions is discussed
Original languageEnglish
Pages (from-to)409-418
Issue number3
Publication statusPublished - 2003


  • biosynthesis
  • step


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