Human respiratory syncytial virus infection in the pre-clinical calf model

B. Cortjens*, R. de Jong, J.G. Bonsing, J.B.M. van Woensel, R.A. Bem, A.F.G. Antonis

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume65
DOIs
Publication statusPublished - 1 Aug 2019

Keywords

  • Animal model
  • Bronchiolitis
  • Calves
  • Neutrophil
  • Respiratory syncytial virus
  • Upper and lower respiratory tract infections

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