Human respiratory syncytial virus infection in the pre-clinical calf model

B. Cortjens; R. de Jong; J.G. Bonsing; J.B.M. van Woensel; R.A. Bem; A.F.G. Antonis

doi:10.1016/j.cimid.2019.04.006

Human respiratory syncytial virus infection in the pre-clinical calf model

B. Cortjens^*, R. de Jong, J.G. Bonsing, J.B.M. van Woensel, R.A. Bem, A.F.G. Antonis

^*Corresponding author for this work

Virology & Molecular Biology

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.

Original language	English
Pages (from-to)	213-218
Number of pages	6
Journal	Comparative Immunology, Microbiology and Infectious Diseases
Volume	65
DOIs	https://doi.org/10.1016/j.cimid.2019.04.006
Publication status	Published - 1 Aug 2019

Keywords

Animal model
Bronchiolitis
Calves
Neutrophil
Respiratory syncytial virus
Upper and lower respiratory tract infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cimid.2019.04.006

Cite this

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title = "Human respiratory syncytial virus infection in the pre-clinical calf model",

abstract = "Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.",

keywords = "Animal model, Bronchiolitis, Calves, Neutrophil, Respiratory syncytial virus, Upper and lower respiratory tract infections",

author = "B. Cortjens and {de Jong}, R. and J.G. Bonsing and {van Woensel}, J.B.M. and R.A. Bem and A.F.G. Antonis",

year = "2019",

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doi = "10.1016/j.cimid.2019.04.006",

language = "English",

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journal = "Comparative Immunology, Microbiology and Infectious Diseases",

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T1 - Human respiratory syncytial virus infection in the pre-clinical calf model

AU - Cortjens, B.

AU - de Jong, R.

AU - Bonsing, J.G.

AU - van Woensel, J.B.M.

AU - Bem, R.A.

AU - Antonis, A.F.G.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.

AB - Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.

KW - Animal model

KW - Bronchiolitis

KW - Calves

KW - Neutrophil

KW - Respiratory syncytial virus

KW - Upper and lower respiratory tract infections

U2 - 10.1016/j.cimid.2019.04.006

DO - 10.1016/j.cimid.2019.04.006

M3 - Article

AN - SCOPUS:85067488633

SN - 0147-9571

VL - 65

SP - 213

EP - 218

JO - Comparative Immunology, Microbiology and Infectious Diseases

JF - Comparative Immunology, Microbiology and Infectious Diseases

ER -

Human respiratory syncytial virus infection in the pre-clinical calf model

Abstract

Keywords

UN SDGs

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