Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups

M. Elwakiel, J.A. Hageman, W. Wang, I.M. Szeto, J.B. van Goudoever, K.A. Hettinga, H.A. Schols

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

To study the variability in human milk oligosaccharide (HMO) composition of Chinese human milk over a 20-wk lactation period, HMO profiles of 30 mothers were analyzed using CE-LIF. This study showed that total HMO concentrations in Chinese human milk decreased significantly over a 20-wk lactation period, independent of the mother's SeLe status, although with individual variations. In addition, total acidic and neutral HMO concentrations in Chinese human milk decreased over lactation, and levels are driven by their mother's SeLe status. Analysis showed that total neutral fucosylated HMO concentrations in Chinese human milk were higher in the two secretor groups as compared to the nonsecretor group. On the basis of the total neutral fucosylated HMO concentrations in Chinese human milk, HMO profiles within the Se+Le+ group can be divided into two subgroups. HMOs that differed in level between Se+Le+ subgroups were 2′FL, DF-L, LNFP I, and F-LNO. HMO profiles in Dutch human milk also showed Se+Le+ subgroup division, with 2′FL, LNT, and F-LNO as the driving force.

LanguageEnglish
Pages7036-7043
JournalJournal of Agricultural and Food Chemistry
Volume66
Issue number27
DOIs
Publication statusPublished - 11 Jul 2018

Fingerprint

Colostrum
Human Milk
breast milk
colostrum
Oligosaccharides
oligosaccharides
Milk
Mothers
milk
Lactation
lactation
Health Maintenance Organizations

Keywords

  • carbohydrates
  • genetic polymorphisms
  • lactation stage
  • variability

Cite this

@article{928d6c0f5dbf46429ab8aa921957ebb6,
title = "Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups",
abstract = "To study the variability in human milk oligosaccharide (HMO) composition of Chinese human milk over a 20-wk lactation period, HMO profiles of 30 mothers were analyzed using CE-LIF. This study showed that total HMO concentrations in Chinese human milk decreased significantly over a 20-wk lactation period, independent of the mother's SeLe status, although with individual variations. In addition, total acidic and neutral HMO concentrations in Chinese human milk decreased over lactation, and levels are driven by their mother's SeLe status. Analysis showed that total neutral fucosylated HMO concentrations in Chinese human milk were higher in the two secretor groups as compared to the nonsecretor group. On the basis of the total neutral fucosylated HMO concentrations in Chinese human milk, HMO profiles within the Se+Le+ group can be divided into two subgroups. HMOs that differed in level between Se+Le+ subgroups were 2′FL, DF-L, LNFP I, and F-LNO. HMO profiles in Dutch human milk also showed Se+Le+ subgroup division, with 2′FL, LNT, and F-LNO as the driving force.",
keywords = "carbohydrates, genetic polymorphisms, lactation stage, variability",
author = "M. Elwakiel and J.A. Hageman and W. Wang and I.M. Szeto and {van Goudoever}, J.B. and K.A. Hettinga and H.A. Schols",
year = "2018",
month = "7",
day = "11",
doi = "10.1021/acs.jafc.8b02021",
language = "English",
volume = "66",
pages = "7036--7043",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "27",

}

Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers : Lewis Positive Secretor Subgroups. / Elwakiel, M.; Hageman, J.A.; Wang, W.; Szeto, I.M.; van Goudoever, J.B.; Hettinga, K.A.; Schols, H.A.

In: Journal of Agricultural and Food Chemistry, Vol. 66, No. 27, 11.07.2018, p. 7036-7043.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers

T2 - Journal of Agricultural and Food Chemistry

AU - Elwakiel, M.

AU - Hageman, J.A.

AU - Wang, W.

AU - Szeto, I.M.

AU - van Goudoever, J.B.

AU - Hettinga, K.A.

AU - Schols, H.A.

PY - 2018/7/11

Y1 - 2018/7/11

N2 - To study the variability in human milk oligosaccharide (HMO) composition of Chinese human milk over a 20-wk lactation period, HMO profiles of 30 mothers were analyzed using CE-LIF. This study showed that total HMO concentrations in Chinese human milk decreased significantly over a 20-wk lactation period, independent of the mother's SeLe status, although with individual variations. In addition, total acidic and neutral HMO concentrations in Chinese human milk decreased over lactation, and levels are driven by their mother's SeLe status. Analysis showed that total neutral fucosylated HMO concentrations in Chinese human milk were higher in the two secretor groups as compared to the nonsecretor group. On the basis of the total neutral fucosylated HMO concentrations in Chinese human milk, HMO profiles within the Se+Le+ group can be divided into two subgroups. HMOs that differed in level between Se+Le+ subgroups were 2′FL, DF-L, LNFP I, and F-LNO. HMO profiles in Dutch human milk also showed Se+Le+ subgroup division, with 2′FL, LNT, and F-LNO as the driving force.

AB - To study the variability in human milk oligosaccharide (HMO) composition of Chinese human milk over a 20-wk lactation period, HMO profiles of 30 mothers were analyzed using CE-LIF. This study showed that total HMO concentrations in Chinese human milk decreased significantly over a 20-wk lactation period, independent of the mother's SeLe status, although with individual variations. In addition, total acidic and neutral HMO concentrations in Chinese human milk decreased over lactation, and levels are driven by their mother's SeLe status. Analysis showed that total neutral fucosylated HMO concentrations in Chinese human milk were higher in the two secretor groups as compared to the nonsecretor group. On the basis of the total neutral fucosylated HMO concentrations in Chinese human milk, HMO profiles within the Se+Le+ group can be divided into two subgroups. HMOs that differed in level between Se+Le+ subgroups were 2′FL, DF-L, LNFP I, and F-LNO. HMO profiles in Dutch human milk also showed Se+Le+ subgroup division, with 2′FL, LNT, and F-LNO as the driving force.

KW - carbohydrates

KW - genetic polymorphisms

KW - lactation stage

KW - variability

U2 - 10.1021/acs.jafc.8b02021

DO - 10.1021/acs.jafc.8b02021

M3 - Article

VL - 66

SP - 7036

EP - 7043

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 27

ER -