How to manipulate the microbiota: Fecal microbiota transplantation

Susana Fuentes Enriquez de Salamanca, Willem M. de Vos

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

17 Citations (Scopus)

Abstract

Fecal microbiota transplantation (FMT) is a rather straightforward therapy that manipulates the human gastrointestinal (GI) microbiota, by which a healthy donor microbiota is transferred into an existing but disturbed microbial ecosystem. This is a natural process that occurs already at birth; infants are rapidly colonized by a specific microbial community, the composition of which strongly depends on the mode of delivery and which therefore most likely originates from the mother (Palmer et al. 2007; Tannock et al. 1990). Since this early life microbial community already contains most, if not all, of the predominantly anaerobic microbes that are only found in the GI tract, it is reasonable to assume that early life colonization is the ultimate natural fecal transplantation.

Original languageEnglish
Title of host publicationMicrobiota of the Human Body
EditorsAndreas Schwiertz
PublisherSpringer
Pages143-153
Volume902
ISBN (Electronic)9783319312484
ISBN (Print)9783319312460
DOIs
Publication statusPublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume902

Keywords

  • Clostridium difficile
  • Donor
  • Gastrointestinal microbiota
  • IBD
  • Microbial ecology
  • Regulation
  • Safety

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