How the COVID-19 pandemic highlights the necessity of animal research

Lisa Genzel; Roger Adan; Anton Berns; Jeroen van den Beucken; Arjan Blokland; Erik H.W.G.M. Boddeke; Willy M. Bogers; Ronald Bontrop; R. Bulthuis; Teun Bousema; Hans Clevers; Tineke C.J.J. Coenen; Anne Marie van Dam; Peter M.T. Deen; K.W. van Dijk; Bart J.L. Eggen; Ype Elgersma; Izel Erdogan; Bernard Englitz; J.M. Fentener van Vlissingen; Susanne la Fleur; Ron Fouchier; Carlos P. Fitzsimons; Wilbert Frieling; Bart Haagmans; Balthasar A. Heesters; Marloes Henckens; Sander Herfst; Elly Hol; Daniel van den Hove; Marien I. de Jonge; Jos Jonkers; Leo A.B. Joosten; Andries Kalsbeek; Maarten Kamermans; Harm H. Kampinga; Martien J. Kas; J. Keijer; Sander Kersten; Amanda J. Kiliaan; Taco W.A. Kooij; Sander Kooijman; Werner J.H. Koopman; Aniko Korosi; Harm J. Krugers; Thijs Kuiken; Steven A. Kushner; Jan A.M. Langermans; Heidi Lesscher; Paul J. Lucassen; Esther Lutgens; Mihai G. Netea; Lucas P.J.J. Noldus; Jos W.M. van der Meer; Frank J. Meye; Joram D. Mul; Kees van Oers; Jocelien D.A. Olivier; R.J. Pasterkamp; Ingrid H.C.H.M. Philippens; Jos Prickaerts; Bart J.A. Pullox; Patrick C.N. Rensen; Jacco van Rheenen; Ronald P. van Rij; Laila Ritsma; Barry H.G. Rockx; Benno Roozendaal; Evert M. van Schothorst; K. Stittelaar; Norbert Stockhofe; Dick F. Swaab; Rik L. de Swart; Louk J.M.J. Vanderschuren; Taco de Vries; Femke de Vrij; Richard van Wezel; Corette J. Wierenga; Maximilian Wiesmann; Ingo Willuhn; Chris I. de Zeeuw; Judith R. Homberg

doi:10.1016/j.cub.2020.08.030

How the COVID-19 pandemic highlights the necessity of animal research

Lisa Genzel^*, Roger Adan, Anton Berns, Jeroen van den Beucken, Arjan Blokland, Erik H.W.G.M. Boddeke, Willy M. Bogers, Ronald Bontrop, R. Bulthuis, Teun Bousema, Hans Clevers, Tineke C.J.J. Coenen, Anne Marie van Dam, Peter M.T. Deen, K.W. van Dijk, Bart J.L. Eggen, Ype Elgersma, Izel Erdogan, Bernard Englitz, J.M. Fentener van VlissingenSusanne la Fleur, Ron Fouchier, Carlos P. Fitzsimons, Wilbert Frieling, Bart Haagmans, Balthasar A. Heesters, Marloes Henckens, Sander Herfst, Elly Hol, Daniel van den Hove, Marien I. de Jonge, Jos Jonkers, Leo A.B. Joosten, Andries Kalsbeek, Maarten Kamermans, Harm H. Kampinga, Martien J. Kas, J. Keijer, Sander Kersten, Amanda J. Kiliaan, Taco W.A. Kooij, Sander Kooijman, Werner J.H. Koopman, Aniko Korosi, Harm J. Krugers, Thijs Kuiken, Steven A. Kushner, Jan A.M. Langermans, Heidi Lesscher, Paul J. Lucassen, Esther Lutgens, Mihai G. Netea, Lucas P.J.J. Noldus, Jos W.M. van der Meer, Frank J. Meye, Joram D. Mul, Kees van Oers, Jocelien D.A. Olivier, R.J. Pasterkamp, Ingrid H.C.H.M. Philippens, Jos Prickaerts, Bart J.A. Pullox, Patrick C.N. Rensen, Jacco van Rheenen, Ronald P. van Rij, Laila Ritsma, Barry H.G. Rockx, Benno Roozendaal, Evert M. van Schothorst, K. Stittelaar, Norbert Stockhofe, Dick F. Swaab, Rik L. de Swart, Louk J.M.J. Vanderschuren, Taco de Vries, Femke de Vrij, Richard van Wezel, Corette J. Wierenga, Maximilian Wiesmann, Ingo Willuhn, Chris I. de Zeeuw, Judith R. Homberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health. In this Essay, Genzel et al. make the case for animal research in light of the COVID-19 pandemic.

Original language	English
Pages (from-to)	R1014-R1018
Journal	Current Biology
Volume	30
Issue number	18
DOIs	https://doi.org/10.1016/j.cub.2020.08.030
Publication status	Published - 21 Sept 2020

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Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A. M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030

@article{e441af04a0e34e248b3895dc8663ac2b,

title = "How the COVID-19 pandemic highlights the necessity of animal research",

abstract = "Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health. In this Essay, Genzel et al. make the case for animal research in light of the COVID-19 pandemic.",

author = "Lisa Genzel and Roger Adan and Anton Berns and {van den Beucken}, Jeroen and Arjan Blokland and Boddeke, {Erik H.W.G.M.} and Bogers, {Willy M.} and Ronald Bontrop and R. Bulthuis and Teun Bousema and Hans Clevers and Coenen, {Tineke C.J.J.} and {van Dam}, {Anne Marie} and Deen, {Peter M.T.} and {van Dijk}, K.W. and Eggen, {Bart J.L.} and Ype Elgersma and Izel Erdogan and Bernard Englitz and {Fentener van Vlissingen}, J.M. and {la Fleur}, Susanne and Ron Fouchier and Fitzsimons, {Carlos P.} and Wilbert Frieling and Bart Haagmans and Heesters, {Balthasar A.} and Marloes Henckens and Sander Herfst and Elly Hol and {van den Hove}, Daniel and {de Jonge}, {Marien I.} and Jos Jonkers and Joosten, {Leo A.B.} and Andries Kalsbeek and Maarten Kamermans and Kampinga, {Harm H.} and Kas, {Martien J.} and J. Keijer and Sander Kersten and Kiliaan, {Amanda J.} and Kooij, {Taco W.A.} and Sander Kooijman and Koopman, {Werner J.H.} and Aniko Korosi and Krugers, {Harm J.} and Thijs Kuiken and Kushner, {Steven A.} and Langermans, {Jan A.M.} and Heidi Lesscher and Lucassen, {Paul J.} and Esther Lutgens and Netea, {Mihai G.} and Noldus, {Lucas P.J.J.} and {van der Meer}, {Jos W.M.} and Meye, {Frank J.} and Mul, {Joram D.} and {van Oers}, Kees and Olivier, {Jocelien D.A.} and R.J. Pasterkamp and Philippens, {Ingrid H.C.H.M.} and Jos Prickaerts and Pullox, {Bart J.A.} and Rensen, {Patrick C.N.} and {van Rheenen}, Jacco and {van Rij}, {Ronald P.} and Laila Ritsma and Rockx, {Barry H.G.} and Benno Roozendaal and {van Schothorst}, {Evert M.} and K. Stittelaar and Norbert Stockhofe and Swaab, {Dick F.} and {de Swart}, {Rik L.} and Vanderschuren, {Louk J.M.J.} and {de Vries}, Taco and {de Vrij}, Femke and {van Wezel}, Richard and Wierenga, {Corette J.} and Maximilian Wiesmann and Ingo Willuhn and {de Zeeuw}, {Chris I.} and Homberg, {Judith R.}",

year = "2020",

month = sep,

day = "21",

doi = "10.1016/j.cub.2020.08.030",

language = "English",

volume = "30",

pages = "R1014--R1018",

journal = "Current Biology",

issn = "0960-9822",

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number = "18",

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Genzel, L, Adan, R, Berns, A, van den Beucken, J, Blokland, A, Boddeke, EHWGM, Bogers, WM, Bontrop, R, Bulthuis, R, Bousema, T, Clevers, H, Coenen, TCJJ, van Dam, AM, Deen, PMT, van Dijk, KW, Eggen, BJL, Elgersma, Y, Erdogan, I, Englitz, B, Fentener van Vlissingen, JM, la Fleur, S, Fouchier, R, Fitzsimons, CP, Frieling, W, Haagmans, B, Heesters, BA, Henckens, M, Herfst, S, Hol, E, van den Hove, D, de Jonge, MI, Jonkers, J, Joosten, LAB, Kalsbeek, A, Kamermans, M, Kampinga, HH, Kas, MJ, Keijer, J , Kersten, S, Kiliaan, AJ, Kooij, TWA, Kooijman, S, Koopman, WJH, Korosi, A, Krugers, HJ, Kuiken, T, Kushner, SA, Langermans, JAM, Lesscher, H, Lucassen, PJ, Lutgens, E, Netea, MG, Noldus, LPJJ, van der Meer, JWM, Meye, FJ, Mul, JD, van Oers, K, Olivier, JDA, Pasterkamp, RJ, Philippens, IHCHM, Prickaerts, J, Pullox, BJA, Rensen, PCN, van Rheenen, J, van Rij, RP, Ritsma, L, Rockx, BHG, Roozendaal, B, van Schothorst, EM, Stittelaar, K, Stockhofe, N, Swaab, DF, de Swart, RL, Vanderschuren, LJMJ, de Vries, T, de Vrij, F, van Wezel, R, Wierenga, CJ, Wiesmann, M, Willuhn, I, de Zeeuw, CI & Homberg, JR 2020, 'How the COVID-19 pandemic highlights the necessity of animal research', Current Biology, vol. 30, no. 18, pp. R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030

TY - JOUR

T1 - How the COVID-19 pandemic highlights the necessity of animal research

AU - Genzel, Lisa

AU - Adan, Roger

AU - Berns, Anton

AU - van den Beucken, Jeroen

AU - Blokland, Arjan

AU - Boddeke, Erik H.W.G.M.

AU - Bogers, Willy M.

AU - Bontrop, Ronald

AU - Bulthuis, R.

AU - Bousema, Teun

AU - Clevers, Hans

AU - Coenen, Tineke C.J.J.

AU - van Dam, Anne Marie

AU - Deen, Peter M.T.

AU - van Dijk, K.W.

AU - Eggen, Bart J.L.

AU - Elgersma, Ype

AU - Erdogan, Izel

AU - Englitz, Bernard

AU - Fentener van Vlissingen, J.M.

AU - la Fleur, Susanne

AU - Fouchier, Ron

AU - Fitzsimons, Carlos P.

AU - Frieling, Wilbert

AU - Haagmans, Bart

AU - Heesters, Balthasar A.

AU - Henckens, Marloes

AU - Herfst, Sander

AU - Hol, Elly

AU - van den Hove, Daniel

AU - de Jonge, Marien I.

AU - Jonkers, Jos

AU - Joosten, Leo A.B.

AU - Kalsbeek, Andries

AU - Kamermans, Maarten

AU - Kampinga, Harm H.

AU - Kas, Martien J.

AU - Keijer, J.

AU - Kersten, Sander

AU - Kiliaan, Amanda J.

AU - Kooij, Taco W.A.

AU - Kooijman, Sander

AU - Koopman, Werner J.H.

AU - Korosi, Aniko

AU - Krugers, Harm J.

AU - Kuiken, Thijs

AU - Kushner, Steven A.

AU - Langermans, Jan A.M.

AU - Lesscher, Heidi

AU - Lucassen, Paul J.

AU - Lutgens, Esther

AU - Netea, Mihai G.

AU - Noldus, Lucas P.J.J.

AU - van der Meer, Jos W.M.

AU - Meye, Frank J.

AU - Mul, Joram D.

AU - van Oers, Kees

AU - Olivier, Jocelien D.A.

AU - Pasterkamp, R.J.

AU - Philippens, Ingrid H.C.H.M.

AU - Prickaerts, Jos

AU - Pullox, Bart J.A.

AU - Rensen, Patrick C.N.

AU - van Rheenen, Jacco

AU - van Rij, Ronald P.

AU - Ritsma, Laila

AU - Rockx, Barry H.G.

AU - Roozendaal, Benno

AU - van Schothorst, Evert M.

AU - Stittelaar, K.

AU - Stockhofe, Norbert

AU - Swaab, Dick F.

AU - de Swart, Rik L.

AU - Vanderschuren, Louk J.M.J.

AU - de Vries, Taco

AU - de Vrij, Femke

AU - van Wezel, Richard

AU - Wierenga, Corette J.

AU - Wiesmann, Maximilian

AU - Willuhn, Ingo

AU - de Zeeuw, Chris I.

AU - Homberg, Judith R.

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health. In this Essay, Genzel et al. make the case for animal research in light of the COVID-19 pandemic.

AB - Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health. In this Essay, Genzel et al. make the case for animal research in light of the COVID-19 pandemic.

U2 - 10.1016/j.cub.2020.08.030

DO - 10.1016/j.cub.2020.08.030

M3 - Article

C2 - 32961149

AN - SCOPUS:85090938421

SN - 0960-9822

VL - 30

SP - R1014-R1018

JO - Current Biology

JF - Current Biology

IS - 18

ER -

How the COVID-19 pandemic highlights the necessity of animal research

Abstract

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