The outcome of an infection is determined by numerous interactions between hosts and pathogens occurring at many different biological levels, ranging from molecule to population. To develop new control strategies for infectious diseases in livestock species, appropriate methodologies are needed allowing more integrated system-level analysis in order to get a coherent picture of host–pathogen interaction networks. The field of systems biology provides such new concepts and methodologies. The chapter describes the first steps in the application of systems biology to study the interaction between two highly interacting biological systems: the invading pathogen and the defending host. Several examples of the application of system biology in this area of infection biology are described. It is concluded that these new approaches may provide a sound innovative basis for improving the prevention and control of infectious diseases in farmed animals.
|Title of host publication||Systems Biology and Livestock Science|
|Editors||M.F.W. Pas, H. Woelders, A. Bannink|
|Place of Publication||Chichester [etc.]|
|Publisher||John Wiley and Sons|
|Number of pages||332|
|Publication status||Published - 2011|