Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11

C.W. Ang, J.R. Dijkstra, M.A. de Klerk, H.P. Endtz, P.A. Doorn, B.C. Jacobs, S.H.M. Jeurissen, J.A. Wagenaar

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    8 Citations (Scopus)

    Abstract

    Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry. Immunization studies in rabbits and mice have demonstrated that these anti-ganglioside antibodies can be induced using purified lipo-oligosaccharides (LOS) from C. jejuni in a strong adjuvant. Methodology/Principal Findings: To investigate whether natural colonization of chickens with a ganglioside-mimicking C. jejuni strain induces an anti-ganglioside response, and to investigate the diversity in anti-ganglioside response between and within genetically different chicken lines, we orally challenged chickens with different C. jejuni strains. Oral challenge of chickens with a C. jejuni strain from a GBS patient, containing a LOS that mimics ganglioside GM1, induced specific IgM and IgG anti-LOS and anti-GM1 antibodies. Inoculation of chickens with the Penner HS:3 serostrain, without a GM1-like structure, induced anti-LOS but no anti-ganglioside antibodies. We observed different patterns of anti-LOS/ganglioside response between and within the five strains of chickens. Conclusions: Natural infection of chickens with C. jejuni induces anti-ganglioside antibodies. The production of antibodies is governed by both microbial and host factors.
    Original languageEnglish
    Article numbere9820
    Number of pages7
    JournalPLoS ONE
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - 2010

    Keywords

    • miller-fisher-syndrome
    • lipopolysaccharides
    • antibodies
    • infection
    • colonization
    • gangliosides
    • enteritis
    • exchange
    • mimicry
    • rabbits

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    Ang, C. W., Dijkstra, J. R., de Klerk, M. A., Endtz, H. P., Doorn, P. A., Jacobs, B. C., Jeurissen, S. H. M., & Wagenaar, J. A. (2010). Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11. PLoS ONE, 5(3), [e9820]. https://doi.org/10.1371/journal.pone.0009820