Host and Environmental Factors Influencing Individual Human Cytokine Responses

Rob ter Horst; Martin Jaeger; Sanne P. Smeekens; Marije Oosting; Morris A. Swertz; Yang Li; Vinod Kumar; Dimitri A. Diavatopoulos; Anne F.M. Jansen; Heidi Lemmers; Helga Toenhake-Dijkstra; Antonius E. van Herwaarden; Matthijs Janssen; Renate G. van der Molen; Irma Joosten; Fred C.G.J. Sweep; Johannes W. Smit; Romana T. Netea-Maier; Mieke M.J.F. Koenders; Ramnik J. Xavier; Jos W.M. van der Meer; Charles A. Dinarello; Norman Pavelka; Cisca Wijmenga; Richard A. Notebaart; Leo A.B. Joosten; Mihai G. Netea

doi:10.1016/j.cell.2016.10.018

Host and Environmental Factors Influencing Individual Human Cytokine Responses

Rob ter Horst, Martin Jaeger, Sanne P. Smeekens, Marije Oosting, Morris A. Swertz, Yang Li, Vinod Kumar, Dimitri A. Diavatopoulos, Anne F.M. Jansen, Heidi Lemmers, Helga Toenhake-Dijkstra, Antonius E. van Herwaarden, Matthijs Janssen, Renate G. van der Molen, Irma Joosten, Fred C.G.J. Sweep, Johannes W. Smit, Romana T. Netea-Maier, Mieke M.J.F. Koenders, Ramnik J. XavierJos W.M. van der Meer, Charles A. Dinarello, Norman Pavelka, Cisca Wijmenga, Richard A. Notebaart, Leo A.B. Joosten^*, Mihai G. Netea

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

351 Citations (Scopus)

Abstract

Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PaperClip

Original language	English
Pages (from-to)	1111-1124.e13
Journal	Cell
Volume	167
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2016.10.018
Publication status	Published - 3 Nov 2016
Externally published	Yes

Keywords

age
alpha-1-antitrypsin
cytokines
environment
gender
genetics
host
microbiome
season
vitamin D

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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ter Horst, R., Jaeger, M., Smeekens, S. P., Oosting, M., Swertz, M. A., Li, Y., Kumar, V., Diavatopoulos, D. A., Jansen, A. F. M., Lemmers, H., Toenhake-Dijkstra, H., van Herwaarden, A. E., Janssen, M., van der Molen, R. G., Joosten, I., Sweep, F. C. G. J., Smit, J. W., Netea-Maier, R. T., Koenders, M. M. J. F., ... Netea, M. G. (2016). Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell, 167(4), 1111-1124.e13. https://doi.org/10.1016/j.cell.2016.10.018

@article{78122b8845fa4ae79d55870472d5da77,

title = "Host and Environmental Factors Influencing Individual Human Cytokine Responses",

abstract = "Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PaperClip",

keywords = "age, alpha-1-antitrypsin, cytokines, environment, gender, genetics, host, microbiome, season, vitamin D",

author = "{ter Horst}, Rob and Martin Jaeger and Smeekens, {Sanne P.} and Marije Oosting and Swertz, {Morris A.} and Yang Li and Vinod Kumar and Diavatopoulos, {Dimitri A.} and Jansen, {Anne F.M.} and Heidi Lemmers and Helga Toenhake-Dijkstra and {van Herwaarden}, {Antonius E.} and Matthijs Janssen and {van der Molen}, {Renate G.} and Irma Joosten and Sweep, {Fred C.G.J.} and Smit, {Johannes W.} and Netea-Maier, {Romana T.} and Koenders, {Mieke M.J.F.} and Xavier, {Ramnik J.} and {van der Meer}, {Jos W.M.} and Dinarello, {Charles A.} and Norman Pavelka and Cisca Wijmenga and Notebaart, {Richard A.} and Joosten, {Leo A.B.} and Netea, {Mihai G.}",

year = "2016",

month = nov,

day = "3",

doi = "10.1016/j.cell.2016.10.018",

language = "English",

volume = "167",

pages = "1111--1124.e13",

journal = "Cell",

issn = "0092-8674",

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}

ter Horst, R, Jaeger, M, Smeekens, SP, Oosting, M, Swertz, MA, Li, Y, Kumar, V, Diavatopoulos, DA, Jansen, AFM, Lemmers, H, Toenhake-Dijkstra, H, van Herwaarden, AE, Janssen, M, van der Molen, RG, Joosten, I, Sweep, FCGJ, Smit, JW, Netea-Maier, RT, Koenders, MMJF, Xavier, RJ, van der Meer, JWM, Dinarello, CA, Pavelka, N, Wijmenga, C, Notebaart, RA, Joosten, LAB & Netea, MG 2016, 'Host and Environmental Factors Influencing Individual Human Cytokine Responses', Cell, vol. 167, no. 4, pp. 1111-1124.e13. https://doi.org/10.1016/j.cell.2016.10.018

TY - JOUR

T1 - Host and Environmental Factors Influencing Individual Human Cytokine Responses

AU - ter Horst, Rob

AU - Jaeger, Martin

AU - Smeekens, Sanne P.

AU - Oosting, Marije

AU - Swertz, Morris A.

AU - Li, Yang

AU - Kumar, Vinod

AU - Diavatopoulos, Dimitri A.

AU - Jansen, Anne F.M.

AU - Lemmers, Heidi

AU - Toenhake-Dijkstra, Helga

AU - van Herwaarden, Antonius E.

AU - Janssen, Matthijs

AU - van der Molen, Renate G.

AU - Joosten, Irma

AU - Sweep, Fred C.G.J.

AU - Smit, Johannes W.

AU - Netea-Maier, Romana T.

AU - Koenders, Mieke M.J.F.

AU - Xavier, Ramnik J.

AU - van der Meer, Jos W.M.

AU - Dinarello, Charles A.

AU - Pavelka, Norman

AU - Wijmenga, Cisca

AU - Notebaart, Richard A.

AU - Joosten, Leo A.B.

AU - Netea, Mihai G.

PY - 2016/11/3

Y1 - 2016/11/3

N2 - Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PaperClip

AB - Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PaperClip

KW - age

KW - alpha-1-antitrypsin

KW - cytokines

KW - environment

KW - gender

KW - genetics

KW - host

KW - microbiome

KW - season

KW - vitamin D

U2 - 10.1016/j.cell.2016.10.018

DO - 10.1016/j.cell.2016.10.018

M3 - Article

C2 - 27814508

AN - SCOPUS:84994747507

SN - 0092-8674

VL - 167

SP - 1111-1124.e13

JO - Cell

JF - Cell

IS - 4

ER -

Host and Environmental Factors Influencing Individual Human Cytokine Responses

Abstract

Keywords

UN SDGs

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