Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people

R.A.M. Dhonukshe-Rutten, S.M.F. Pluijm, C.P.G.M. de Groot, P. Lips, J.H. Smit, W.A. van Staveren

Research output: Contribution to journalArticleAcademicpeer-review

164 Citations (Scopus)

Abstract

Hyperhomocysteinemia may contribute to the development of osteoporosis. The relationship of Hcy and vitamin B12 with bone turnover markers, BUA, and fracture incidence was studied in 1267 subjects of the Longitudinal Aging Study Amsterdam. High Hcy and low vitamin B12 concentrations were significantly associated with low BUA, high markers of bone turnover, and increased fracture risk
Original languageEnglish
Pages (from-to)921-929
JournalJournal of Bone and Mineral Research
Volume20
Issue number6
DOIs
Publication statusPublished - 2005

Keywords

  • hormone replacement therapy
  • hip fracture
  • osteoporotic fractures
  • postmenopausal women
  • mineral density
  • cobalamin deficiency
  • biochemical markers
  • methylmalonic acid
  • quantitative ultrasound
  • plasma homocysteine

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