TY - JOUR
T1 - Hollow protein microparticles formed through cross-linking by an Au3+ initiated redox reaction
AU - Schijven, Laura M.I.
AU - Vogelaar, Thomas D.
AU - Sridharan, Simha
AU - Saggiomo, Vittorio
AU - Velders, Aldrik H.
AU - Bitter, Johannes H.
AU - Nikiforidis, Constantinos V.
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry
PY - 2022/9/7
Y1 - 2022/9/7
N2 - Hollow microparticles (MPs) are of great relevance in the materials industry for a wide range of applications, such as catalysis, coatings, and delivery of theranostics. Here, we report the formation of hollow MPs through the assembly of lipoproteins in CaCO3 templates. Proteins interact in the pores of CaCO3 templates through attractive hydrophobic forces and form dense edges of hollow MPs. To further cross-link the proteins, Au3+ was added to initiate a redox reaction, where proteins were oxidized forming inter- and intramolecular covalent bonds, while Au3+ was reduced and gold nanoparticles (AuNPs) were formed. The obtained protein-based hollow MPs have a diameter of 6 μm and the AuNPs are embedded on their surface. Through this research, we suggest a new route to design biobased Au-protein hollow MPs in simple steps, which can allow new possibilities for carrying functional molecules and bioimaging.
AB - Hollow microparticles (MPs) are of great relevance in the materials industry for a wide range of applications, such as catalysis, coatings, and delivery of theranostics. Here, we report the formation of hollow MPs through the assembly of lipoproteins in CaCO3 templates. Proteins interact in the pores of CaCO3 templates through attractive hydrophobic forces and form dense edges of hollow MPs. To further cross-link the proteins, Au3+ was added to initiate a redox reaction, where proteins were oxidized forming inter- and intramolecular covalent bonds, while Au3+ was reduced and gold nanoparticles (AuNPs) were formed. The obtained protein-based hollow MPs have a diameter of 6 μm and the AuNPs are embedded on their surface. Through this research, we suggest a new route to design biobased Au-protein hollow MPs in simple steps, which can allow new possibilities for carrying functional molecules and bioimaging.
U2 - 10.1039/d2tb00823h
DO - 10.1039/d2tb00823h
M3 - Article
AN - SCOPUS:85132360166
VL - 10
SP - 6287
EP - 6295
JO - Journal of materials chemistry. B, Materials for biology and medicine
JF - Journal of materials chemistry. B, Materials for biology and medicine
SN - 2050-7518
IS - 33
ER -