@inproceedings{77dd6f2e749c49bc8fbe292679baccb0,
title = "Highly sensitive integrated optical biosensing platform based on an asymmetric Mach-Zehnder interferometer and material-selective (bio)functionalization",
abstract = "An innovative integrated optical biosensing platform with an extremely high sensitivity is presented. The platform uses TriPleX (Si3N4/SiO2) waveguide technology in an asymmetric Mach-Zehnder Interferometer (aMZI) configuration, which is intrinsically more sensitive than other waveguide-based sensor technologies and Surface Plasmon Resonance (SPR). The performance of the sensor is enhanced by material-selective functionalization of Si3N4 vs. SiO2, allowing site-selective immobilization of the bioreceptor to the waveguide surface. The rest of the chip surface is modified with an antifouling layer to reduce non-specific adsorption. Analyte binding is thus confined to the waveguide surface, which results in improved sensitivity and limit of detection.",
keywords = "Integrated optics, Optical detection, Surface modification",
author = "W. Knoben and G. Besselink and E. Roeven and H. Zuilhof and A. Sch{\"u}tz-Trilling and {van der Meer}, A. and L. Scheres and H. Leeuwis and F. Falke and F. Schreuder and R. Heideman and {van den Vlekkert}, H.",
year = "2018",
month = jan,
day = "1",
language = "English",
series = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
publisher = "Chemical and Biological Microsystems Society",
pages = "982--985",
booktitle = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 ; Conference date: 11-11-2018 Through 15-11-2018",
}