Highly sensitive integrated optical biosensing platform based on an asymmetric Mach-Zehnder interferometer and material-selective (bio)functionalization

W. Knoben, G. Besselink, E. Roeven, H. Zuilhof, A. Schütz-Trilling, A. van der Meer, L. Scheres, H. Leeuwis, F. Falke, F. Schreuder, R. Heideman, H. van den Vlekkert

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

An innovative integrated optical biosensing platform with an extremely high sensitivity is presented. The platform uses TriPleX (Si3N4/SiO2) waveguide technology in an asymmetric Mach-Zehnder Interferometer (aMZI) configuration, which is intrinsically more sensitive than other waveguide-based sensor technologies and Surface Plasmon Resonance (SPR). The performance of the sensor is enhanced by material-selective functionalization of Si3N4 vs. SiO2, allowing site-selective immobilization of the bioreceptor to the waveguide surface. The rest of the chip surface is modified with an antifouling layer to reduce non-specific adsorption. Analyte binding is thus confined to the waveguide surface, which results in improved sensitivity and limit of detection.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages982-985
Number of pages4
ISBN (Electronic)9781510897571
Publication statusPublished - 1 Jan 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 11 Nov 201815 Nov 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume2

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1815/11/18

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Keywords

  • Integrated optics
  • Optical detection
  • Surface modification

Cite this

Knoben, W., Besselink, G., Roeven, E., Zuilhof, H., Schütz-Trilling, A., van der Meer, A., ... van den Vlekkert, H. (2018). Highly sensitive integrated optical biosensing platform based on an asymmetric Mach-Zehnder interferometer and material-selective (bio)functionalization. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 982-985). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 2). Chemical and Biological Microsystems Society.