Highly sensitive detection of tumor-derived extracellular vesicles using an enzymatic assay and redox cycling

Dilu G. Mathew, Pepijn Beekman*, Serge G. Lemay, Séverine Le Gac, Wilfred G. van der Wiel

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

Abstract

We report a highly sensitive and specific nanobiosensor for the detection of tumor-derived extracellular vesicles (tdEVs) with a limit of detection of 10 tdEVs/μL. After selective capture on surface modified electrodes, we use a combination of an enzymatic sandwich assay and redox cycling between nanointerdigitated electrodes (nIDEs).

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages76-77
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Enzymatic sandwich assay
  • Nanoelectrodes
  • Redox cycling
  • Tumor-derived extracellular vesicles

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