High-pressure processing for preservation of blood products

A.M. Matser, C. van der Ven, C.W.N. Gouwerok, D. de Korte

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    The possibilities of high pressure as a preservation method for human blood products were evaluated by examining the functional properties of blood fractions, after high-pressure processing at conditions which potentially inactivate micro-organisms and viruses. Blood platelets, red blood cells and blood plasma were pressurised at 200-500 MPa at starting temperatures of 18 °C (platelets), 6 °C (cells and plasma) or -10 °C (plasma). These treatments resulted in considerable loss of the functional properties, i.e., shape change and fragmentation of blood platelets, hemolysis and gelation in red blood cells and loss of fVIII activity in blood plasma. Therefore, high-pressure processing at these conditions seems not interesting for preservation of blood products.
    Original languageEnglish
    Pages (from-to)37-41
    JournalInternational Journal of High Pressure Research
    Volume25
    Issue number1
    DOIs
    Publication statusPublished - 2005

    Keywords

    • temperature
    • plasma

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