High local substrate availability stabilizes a cooperative trait

H. Bachmann, D. Molenaar, M. Kleerebezem, J.E.T. van Hylckama Vlieg

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Abstract

Cooperative behavior is widely spread in microbial populations. An example is the expression of an extracellular protease by the lactic acid bacterium Lactococcus lactis, which degrades milk proteins into free utilizable peptides that are essential to allow growth to high cell densities in milk. Cheating, protease-negative strains can invade the population and drive the protease-positive strain to extinction. By using multiple experimental approaches, as well as modeling population dynamics, we demonstrate that the persistence of the proteolytic trait is determined by the fraction of the generated peptides that can be captured by the cell before diffusing away from it. The mechanism described is likely to be relevant for the evolutionary stability of many extracellular substrate-degrading enzymes. The ISME Journal (2011) 5, 929-932; doi:10.1038/ismej.2010.179; published online 9 December 2010
Original languageEnglish
Pages (from-to)929-932
JournalISME Journal
Volume5
Issue number5
DOIs
Publication statusPublished - 2011

    Fingerprint

Keywords

  • rock-paper-scissors
  • lactococcus-lactis
  • streptococcus-cremoris
  • prisoners-dilemma
  • dairy environment
  • snowdrift game
  • yeast
  • competition
  • selection
  • bacteria

Cite this