High-level pan-azole-resistant aspergillosis

Jakko Van Ingen, Henrich A.L. Van Der Lee, Antonius J.M.M. Rijs, Eveline Snelders, Willem J.G. Melchers, Paul E. Verweij*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)


High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The highlevel pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.

Original languageEnglish
Pages (from-to)2343-2345
Number of pages3
JournalJournal of Clinical Microbiology
Issue number7
Publication statusPublished - Jul 2015
Externally publishedYes


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