High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112

F. dos Santos, A. Wegkamp, W.M. de Vos, E.J. Smid, J. Hugenholtz

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)

Abstract

We observed that Lactobacillus reuteri JCM1112 produces B12 and folate. However, the folate/B12 mass ratio found was far below that desired for human consumption (170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.
Original languageEnglish
Pages (from-to)3291-3294
JournalApplied and Environmental Microbiology
Volume74
Issue number10
DOIs
Publication statusPublished - 2008

Keywords

  • lactic-acid bacteria
  • lactococcus-lactis
  • crl1098
  • biosynthesis
  • plantarum
  • cobalamin
  • sequence
  • systems

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