High dietary protein intake, reducing or eliciting insulin resistance?

A. Rietman, J. Schwarz, D. Tome, F.J. Kok, M.R. Mensink

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)

Abstract

Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway.
Original languageEnglish
Pages (from-to)973-979
JournalEuropean Journal of Clinical Nutrition
Volume68
DOIs
Publication statusPublished - 2014

Fingerprint

Dietary Proteins
Insulin Resistance
Branched Chain Amino Acids
Insulin
Sirolimus
Type 2 Diabetes Mellitus
Blood Glucose
Proteins
Diet
Amino Acids

Keywords

  • metabolic risk-factors
  • low-carbohydrate-diet
  • blood-glucose control
  • chain amino-acids
  • weight-loss diet
  • low-fat diets
  • skeletal-muscle
  • body-composition
  • glycemic control
  • mammalian target

Cite this

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title = "High dietary protein intake, reducing or eliciting insulin resistance?",
abstract = "Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway.",
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High dietary protein intake, reducing or eliciting insulin resistance? / Rietman, A.; Schwarz, J.; Tome, D.; Kok, F.J.; Mensink, M.R.

In: European Journal of Clinical Nutrition, Vol. 68, 2014, p. 973-979.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - High dietary protein intake, reducing or eliciting insulin resistance?

AU - Rietman, A.

AU - Schwarz, J.

AU - Tome, D.

AU - Kok, F.J.

AU - Mensink, M.R.

PY - 2014

Y1 - 2014

N2 - Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway.

AB - Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway.

KW - metabolic risk-factors

KW - low-carbohydrate-diet

KW - blood-glucose control

KW - chain amino-acids

KW - weight-loss diet

KW - low-fat diets

KW - skeletal-muscle

KW - body-composition

KW - glycemic control

KW - mammalian target

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JO - European Journal of Clinical Nutrition

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SN - 0954-3007

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