High dietary menaquinone intake is associated with reduces coronary calcification

J.W.J. Beulens, M.L. Bots, F. Atsma, M.L. Bartelink, M. Prokop, J.M. Geleijnse, J.C. Witteman, D.E. Grobbee, Y.T. van der Schouw

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Abstract

Background Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. This may be due to different effects of vitamin K1 (phylloquinone) and vitamin K2 (menaquinone, MK), but few studies included both. Methods We investigated the association of intake of phylloquinone and menaquinone, including its subtypes (MK4¿MK10), with coronary calcification in a cross-sectional study among 564 post-menopausal women. Phylloquinone and menaquinone intake was estimated using a food-frequency questionnaire. Results Sixty-two percent (n = 360) of the women had coronary calcification based on 1.5-mm thick slices. Phylloquinone intake was not associated with coronary calcification with a relative risk (RR) of 1.17 (95%-confidence interval: 0.96¿1.42; ptrend = 0.11) of the highest versus lowest quartile. Menaquinone intake was associated with decreased coronary calcification with an RR of 0.80 (95%-CI: 0.65¿0.98; ptrend = 0.03). Conclusion This study shows that high dietary menaquinone intake, but probably not phylloquinone, is associated with reduced coronary calcification. Adequate menaquinone intakes could therefore be important to prevent cardiovascular disease.
Original languageEnglish
Pages (from-to)489-493
JournalAtherosclerosis
Volume203
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • food frequency questionnaire
  • matrix gla protein
  • vitamin-k
  • computed-tomography
  • vascular calcification
  • arterial calcification
  • phylloquinone intake
  • relative validity
  • heart-disease
  • risk

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    Beulens, J. W. J., Bots, M. L., Atsma, F., Bartelink, M. L., Prokop, M., Geleijnse, J. M., Witteman, J. C., Grobbee, D. E., & van der Schouw, Y. T. (2009). High dietary menaquinone intake is associated with reduces coronary calcification. Atherosclerosis, 203(2), 489-493. https://doi.org/10.1016/j.atherosclerosis.2008.07.010