High adiposity is associated with higher nocturnal and diurnal glycaemia, but not with glycemic variability in older individuals without diabetes

Raymond Noordam*, Neline C. Huurman, Carolien A. Wijsman, Abimbola A. Akintola, Steffy W.M. Jansen, Stephanie Stassen, Marian Beekman, Ondine van de Rest, P.E. Slagboom, Simon P. Mooijaart, Diana van Heemst

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of glycemic variability over a 72-h period in non-diabetic older adults. Methods: This cross-sectional study was conducted in non-diabetic individuals from the Active and Healthy Aging Study (N = 228), Switchbox (N = 116), and the Growing Old Together Study (N = 94). Body mass index (BMI) and waist circumference were measured, and indices of glycemia and glycemic variability were derived from continuous glucose monitoring (CGM) using the Mini-Med® CGM system. Associations between adiposity and CGM were studied separately for the three cohorts, and derived estimates were subsequently meta-analyzed. Results: After meta-analyzing the results from the separate cohorts, individuals with a higher BMI had higher levels of glycemia. Individuals with BMI between 30 and 35 kg/m2 had 0.28 mmol/L [95% confidence interval (CI): 0.12-0.44] higher 72 h-mean glucose concentration, 0.26 mmol/L (0.10-0.42) higher diurnal glucose (6:00 a.m. to 0:00 a.m.), and 0.39 mmol/L (0.19; 0.59) higher nocturnal glucose (3:00 a.m. to 6:00 a.m.) than participants with a normal weight (BMI 18.5-25 kg/m2). However, no associations were observed between higher BMI and glycemic variability. Results for glycemia and glycemic variability were similarly observed for a high waist circumference. Conclusion: High adiposity associates with constant higher mean glucose levels over the day in non-diabetic older adults.

Original languageEnglish
Article number238
JournalFrontiers in Endocrinology
Volume9
DOIs
Publication statusPublished - 14 May 2018

Keywords

  • Adiposity
  • Body composition
  • Continuous glucose monitoring
  • Glycemia
  • Glycemic variability

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