HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations

Annemieke Christine Mulder, Annelies Kroneman, Eelco Franz, Harry Vennema, Anna D. Tulen, Johanna Takkinen, Agnetha Hofhuis, Cornelia Adlhoch, Stephan Aberle, Lorenzo Subissi, Vanessa Suin, Sofie Midgley, Tatiana Kuznetsova, Jacques Izopet, Nicole Pavio, Christine Baechlein, Sally A. Baylisa, Victor M. Corman, Mirko Fabera, Reimar Johne & 27 others Christel Kamp, Juergen J. Wenzel, Suzie Coughlan, Ilaria Di Bartolo, Roberto Bruni, Anna Rita Ciccaglionea, Anna Rosa Garbuglia, Elisabetta Suffredini, Ingeborg Boxman, Boris Hogema, Wim van der Poel, Hans Zaaijera, Rita de Sousaa, Branko Velebit, Ana Avellóna, Maria Buti, Rosina Girones, Josep Quer, Frederik Widén, Heléne Norder, Kristina Nyström, Claudia Bachofen, Roland Sahli, Samreen Ijaza, Samantha Treagus, Michael Kulka, Valentina Rizzi

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.

LanguageEnglish
Article number1800407
JournalEurosurveillance
Volume24
Issue number10
DOIs
Publication statusPublished - 7 Mar 2019

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Hepatitis E virus
Molecular Typing
Hepatitis Viruses
Health
Food
Blood Safety
Hepatitis E
Molecular Epidemiology
Environmental Health
Food Safety
Zoonoses
Meat
Hepatitis
Hospitalization
Public Health
Joints
Genotype
Parturition
Databases
Mortality

Cite this

Mulder, Annemieke Christine ; Kroneman, Annelies ; Franz, Eelco ; Vennema, Harry ; Tulen, Anna D. ; Takkinen, Johanna ; Hofhuis, Agnetha ; Adlhoch, Cornelia ; Aberle, Stephan ; Subissi, Lorenzo ; Suin, Vanessa ; Midgley, Sofie ; Kuznetsova, Tatiana ; Izopet, Jacques ; Pavio, Nicole ; Baechlein, Christine ; Baylisa, Sally A. ; Corman, Victor M. ; Fabera, Mirko ; Johne, Reimar ; Kamp, Christel ; Wenzel, Juergen J. ; Coughlan, Suzie ; Di Bartolo, Ilaria ; Bruni, Roberto ; Ciccaglionea, Anna Rita ; Garbuglia, Anna Rosa ; Suffredini, Elisabetta ; Boxman, Ingeborg ; Hogema, Boris ; van der Poel, Wim ; Zaaijera, Hans ; de Sousaa, Rita ; Velebit, Branko ; Avellóna, Ana ; Buti, Maria ; Girones, Rosina ; Quer, Josep ; Widén, Frederik ; Norder, Heléne ; Nyström, Kristina ; Bachofen, Claudia ; Sahli, Roland ; Ijaza, Samreen ; Treagus, Samantha ; Kulka, Michael ; Rizzi, Valentina. / HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations. In: Eurosurveillance. 2019 ; Vol. 24, No. 10.
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abstract = "Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89{\%}), and sequences of animal (5{\%}), food (6{\%}) or environmental (0.3{\%}) origin are rare. Metadata for human sequences capture mostly sex (93{\%}), year of birth (92{\%}) and sampling (100{\%}); data on region of sampling (37{\%}) and clinical information (hospitalisation 27{\%}, symptoms 20{\%} or mortality 8{\%}) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.",
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Mulder, AC, Kroneman, A, Franz, E, Vennema, H, Tulen, AD, Takkinen, J, Hofhuis, A, Adlhoch, C, Aberle, S, Subissi, L, Suin, V, Midgley, S, Kuznetsova, T, Izopet, J, Pavio, N, Baechlein, C, Baylisa, SA, Corman, VM, Fabera, M, Johne, R, Kamp, C, Wenzel, JJ, Coughlan, S, Di Bartolo, I, Bruni, R, Ciccaglionea, AR, Garbuglia, AR, Suffredini, E, Boxman, I, Hogema, B, van der Poel, W, Zaaijera, H, de Sousaa, R, Velebit, B, Avellóna, A, Buti, M, Girones, R, Quer, J, Widén, F, Norder, H, Nyström, K, Bachofen, C, Sahli, R, Ijaza, S, Treagus, S, Kulka, M & Rizzi, V 2019, 'HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations', Eurosurveillance, vol. 24, no. 10, 1800407. https://doi.org/10.2807/1560-7917.ES.2019.24.10.1800407

HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations. / Mulder, Annemieke Christine; Kroneman, Annelies; Franz, Eelco; Vennema, Harry; Tulen, Anna D.; Takkinen, Johanna; Hofhuis, Agnetha; Adlhoch, Cornelia; Aberle, Stephan; Subissi, Lorenzo; Suin, Vanessa; Midgley, Sofie; Kuznetsova, Tatiana; Izopet, Jacques; Pavio, Nicole; Baechlein, Christine; Baylisa, Sally A.; Corman, Victor M.; Fabera, Mirko; Johne, Reimar; Kamp, Christel; Wenzel, Juergen J.; Coughlan, Suzie; Di Bartolo, Ilaria; Bruni, Roberto; Ciccaglionea, Anna Rita; Garbuglia, Anna Rosa; Suffredini, Elisabetta; Boxman, Ingeborg; Hogema, Boris; van der Poel, Wim; Zaaijera, Hans; de Sousaa, Rita; Velebit, Branko; Avellóna, Ana; Buti, Maria; Girones, Rosina; Quer, Josep; Widén, Frederik; Norder, Heléne; Nyström, Kristina; Bachofen, Claudia; Sahli, Roland; Ijaza, Samreen; Treagus, Samantha; Kulka, Michael; Rizzi, Valentina.

In: Eurosurveillance, Vol. 24, No. 10, 1800407, 07.03.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations

AU - Mulder, Annemieke Christine

AU - Kroneman, Annelies

AU - Franz, Eelco

AU - Vennema, Harry

AU - Tulen, Anna D.

AU - Takkinen, Johanna

AU - Hofhuis, Agnetha

AU - Adlhoch, Cornelia

AU - Aberle, Stephan

AU - Subissi, Lorenzo

AU - Suin, Vanessa

AU - Midgley, Sofie

AU - Kuznetsova, Tatiana

AU - Izopet, Jacques

AU - Pavio, Nicole

AU - Baechlein, Christine

AU - Baylisa, Sally A.

AU - Corman, Victor M.

AU - Fabera, Mirko

AU - Johne, Reimar

AU - Kamp, Christel

AU - Wenzel, Juergen J.

AU - Coughlan, Suzie

AU - Di Bartolo, Ilaria

AU - Bruni, Roberto

AU - Ciccaglionea, Anna Rita

AU - Garbuglia, Anna Rosa

AU - Suffredini, Elisabetta

AU - Boxman, Ingeborg

AU - Hogema, Boris

AU - van der Poel, Wim

AU - Zaaijera, Hans

AU - de Sousaa, Rita

AU - Velebit, Branko

AU - Avellóna, Ana

AU - Buti, Maria

AU - Girones, Rosina

AU - Quer, Josep

AU - Widén, Frederik

AU - Norder, Heléne

AU - Nyström, Kristina

AU - Bachofen, Claudia

AU - Sahli, Roland

AU - Ijaza, Samreen

AU - Treagus, Samantha

AU - Kulka, Michael

AU - Rizzi, Valentina

PY - 2019/3/7

Y1 - 2019/3/7

N2 - Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.

AB - Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.

U2 - 10.2807/1560-7917.ES.2019.24.10.1800407

DO - 10.2807/1560-7917.ES.2019.24.10.1800407

M3 - Article

VL - 24

JO - Eurosurveillance

T2 - Eurosurveillance

JF - Eurosurveillance

SN - 1025-496X

IS - 10

M1 - 1800407

ER -