Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Fiona A. Hagenbeek; René Pool; Jenny van Dongen; H.M. Draisma; Jouke Jan Hottenga; Gonneke Willemsen; Abdel Abdellaoui; Iryna O. Fedko; Anouk den Braber; Pieter Jelle Visser; Eco J.C.N. de Geus; Ko Willems van Dijk; Aswin Verhoeven; H.E. Suchiman; Marian Beekman; P.E. Slagboom; Cornelia M. van Duijn; J.J.H. Barkey Wolf; D. Cats; N. Amin; J.W. Beulens; J.A. van der Bom; N. Bomer; A. Demirkan; J.A. van Hilten; J.M.T.A. Meessen; M.H. Moed; J. Fu; G.L.J. Onderwater; F. Rutters; C. So-Osman; W.M. van der Flier; A.A.W.A. van der Heijden; A. van der Spek; F.W. Asselbergs; E. Boersma; P.M. Elders; J.M. Geleijnse; M.A. Ikram; M. Kloppenburg; I. Meulenbelt; S.P. Mooijaart; R.G.H.H. Nelissen; M.G. Netea; B.W.J.H. Penninx; C.D.A. Stehouwer; C.E. Teunissen; G.M. Terwindt; J.W. Jukema; M.J.T. Reinders

doi:10.1038/s41467-020-15276-y

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Fiona A. Hagenbeek^*, René Pool, Jenny van Dongen, H.M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J.C.N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H.E. Suchiman, Marian Beekman, P.E. Slagboom, Cornelia M. van Duijn, J.J.H. Barkey Wolf, D. Cats, N. AminJ.W. Beulens, J.A. van der Bom, N. Bomer, A. Demirkan, J.A. van Hilten, J.M.T.A. Meessen, M.H. Moed, J. Fu, G.L.J. Onderwater, F. Rutters, C. So-Osman, W.M. van der Flier, A.A.W.A. van der Heijden, A. van der Spek, F.W. Asselbergs, E. Boersma, P.M. Elders, J.M. Geleijnse, M.A. Ikram, M. Kloppenburg, I. Meulenbelt, S.P. Mooijaart, R.G.H.H. Nelissen, M.G. Netea, B.W.J.H. Penninx, C.D.A. Stehouwer, C.E. Teunissen, G.M. Terwindt, J.W. Jukema, M.J.T. Reinders

^*Corresponding author for this work

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Abstract

The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

Original language	English
Article number	1702
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-15276-y
Publication status	Published - 1 Dec 2020

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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Hottenga, J. J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, E. P., van Duijn, C. M., Barkey Wolf, J. J. H., Cats, D., Amin, N., & 30 othersBeulens, J. W., van der Bom, J. A., Bomer, N., Demirkan, A., van Hilten, J. A., Meessen, J. M. T. A., Moed, M. H., Fu, J., Onderwater, G. L. J., Rutters, F., So-Osman, C., van der Flier, W. M., van der Heijden, A. A. W. A., van der Spek, A., Asselbergs, F. W., Boersma, E., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G. H. H., Netea, M. G., Penninx, B. W. J. H., Stehouwer, C. D. A., Teunissen, C. E., Terwindt, G. M., Jukema, J. W. & Reinders, M. J. T., 7 Jan 2020, In: Nature Communications. 11, 1, 39.
Research output: Contribution to journal › Article › Academic › peer-review

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43 Citations (Scopus)

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Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., van Duijn, C. M., Barkey Wolf, J. J. H., Cats, D., ... Reinders, M. J. T. (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), [1702]. https://doi.org/10.1038/s41467-020-15276-y

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title = "Heritability estimates for 361 blood metabolites across 40 genome-wide association studies",

abstract = "The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.",

author = "Hagenbeek, {Fiona A.} and Ren{\'e} Pool and {van Dongen}, Jenny and H.M. Draisma and {Jan Hottenga}, Jouke and Gonneke Willemsen and Abdel Abdellaoui and Fedko, {Iryna O.} and {den Braber}, Anouk and Visser, {Pieter Jelle} and {de Geus}, {Eco J.C.N.} and {Willems van Dijk}, Ko and Aswin Verhoeven and H.E. Suchiman and Marian Beekman and P.E. Slagboom and {van Duijn}, {Cornelia M.} and {Barkey Wolf}, J.J.H. and D. Cats and N. Amin and J.W. Beulens and {van der Bom}, J.A. and N. Bomer and A. Demirkan and {van Hilten}, J.A. and J.M.T.A. Meessen and M.H. Moed and J. Fu and G.L.J. Onderwater and F. Rutters and C. So-Osman and {van der Flier}, W.M. and {van der Heijden}, A.A.W.A. and {van der Spek}, A. and F.W. Asselbergs and E. Boersma and P.M. Elders and J.M. Geleijnse and M.A. Ikram and M. Kloppenburg and I. Meulenbelt and S.P. Mooijaart and R.G.H.H. Nelissen and M.G. Netea and B.W.J.H. Penninx and C.D.A. Stehouwer and C.E. Teunissen and G.M. Terwindt and J.W. Jukema and M.J.T. Reinders",

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doi = "10.1038/s41467-020-15276-y",

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Hagenbeek, FA, Pool, R, van Dongen, J, Draisma, HM, Jan Hottenga, J, Willemsen, G, Abdellaoui, A, Fedko, IO, den Braber, A, Visser, PJ, de Geus, EJCN, Willems van Dijk, K, Verhoeven, A, Suchiman, HE, Beekman, M, Slagboom, PE, van Duijn, CM, Barkey Wolf, JJH, Cats, D, Amin, N, Beulens, JW, van der Bom, JA, Bomer, N, Demirkan, A, van Hilten, JA, Meessen, JMTA, Moed, MH, Fu, J, Onderwater, GLJ, Rutters, F, So-Osman, C, van der Flier, WM, van der Heijden, AAWA, van der Spek, A, Asselbergs, FW, Boersma, E, Elders, PM, Geleijnse, JM, Ikram, MA, Kloppenburg, M, Meulenbelt, I, Mooijaart, SP, Nelissen, RGHH, Netea, MG, Penninx, BWJH, Stehouwer, CDA, Teunissen, CE, Terwindt, GM, Jukema, JW & Reinders, MJT 2020, 'Heritability estimates for 361 blood metabolites across 40 genome-wide association studies', Nature Communications, vol. 11, no. 1, 1702. https://doi.org/10.1038/s41467-020-15276-y

TY - JOUR

T1 - Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

AU - Hagenbeek, Fiona A.

AU - Pool, René

AU - van Dongen, Jenny

AU - Draisma, H.M.

AU - Jan Hottenga, Jouke

AU - Willemsen, Gonneke

AU - Abdellaoui, Abdel

AU - Fedko, Iryna O.

AU - den Braber, Anouk

AU - Visser, Pieter Jelle

AU - de Geus, Eco J.C.N.

AU - Willems van Dijk, Ko

AU - Verhoeven, Aswin

AU - Suchiman, H.E.

AU - Beekman, Marian

AU - Slagboom, P.E.

AU - van Duijn, Cornelia M.

AU - Barkey Wolf, J.J.H.

AU - Cats, D.

AU - Amin, N.

AU - Beulens, J.W.

AU - van der Bom, J.A.

AU - Bomer, N.

AU - Demirkan, A.

AU - van Hilten, J.A.

AU - Meessen, J.M.T.A.

AU - Moed, M.H.

AU - Fu, J.

AU - Onderwater, G.L.J.

AU - Rutters, F.

AU - So-Osman, C.

AU - van der Flier, W.M.

AU - van der Heijden, A.A.W.A.

AU - van der Spek, A.

AU - Asselbergs, F.W.

AU - Boersma, E.

AU - Elders, P.M.

AU - Geleijnse, J.M.

AU - Ikram, M.A.

AU - Kloppenburg, M.

AU - Meulenbelt, I.

AU - Mooijaart, S.P.

AU - Nelissen, R.G.H.H.

AU - Netea, M.G.

AU - Penninx, B.W.J.H.

AU - Stehouwer, C.D.A.

AU - Teunissen, C.E.

AU - Terwindt, G.M.

AU - Jukema, J.W.

AU - Reinders, M.J.T.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

AB - The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

U2 - 10.1038/s41467-020-15276-y

DO - 10.1038/s41467-020-15276-y

M3 - Comment/Letter to the editor

C2 - 32235831

AN - SCOPUS:85082627876

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1702

ER -

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

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