Heparan sulfate facilitates Rift Valley fever virus entry into the cell

S.M. de Boer, J.A. Kortekaas, C.A. de Haan, P.J.M. Rottier, R.J.M. Moormann, B.J. Bosch

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

Rift Valley fever virus (RVFV), an emerging arthropod-borne pathogen, has a broad host and cell tropism. Here we report that the glycosaminoglycan heparan sulfate, abundantly present on the surface of most animal cells, is required for efficient entry of RVFV. Entry was significantly reduced by preincubating the virus inoculum with highly-sulfated heparin, by enzymatic removal of heparan sulfate from cells and in cells genetically deficient in heparan sulfate synthesis.
Original languageEnglish
Pages (from-to)13767-13771
JournalJournal of Virology
Volume86
Issue number24
DOIs
Publication statusPublished - 2012

Keywords

  • hamster ovary cells
  • protein
  • receptor
  • binding
  • infection
  • biosynthesis
  • glycoprotein
  • replication
  • phlebovirus
  • expression

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