Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops

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    Abstract

    The potential effects of horizontal gene transfer on human health are an important item in the safety assessment of genetically modified organisms. Horizontal gene transfer from genetically modified crops to gut microflora most likely occurs with transgenes of microbial origin. The characteristics of microbial transgenes other than antibiotic-resistance genes in market-approved genetically modified crops are reviewed. These characteristics include the microbial source, natural function, function in genetically modified crops, natural prevalence, geographical distribution, similarity to other microbial genes, known horizontal transfer activity, selective conditions and environments for horizontally transferred genes, and potential contribution to pathogenicity and virulence in humans and animals. The assessment of this set of data for each of the microbial genes reviewed does not give rise to health concerns. We recommend including the above-mentioned items into the premarket safety assessment of genetically modified crops carrying transgenes other than those reviewed in the present study.
    Original languageEnglish
    Pages (from-to)326-352
    JournalJournal of biomedicine and biotechnology
    Volume2005
    Issue number4
    DOIs
    Publication statusPublished - 2005

    Keywords

    • streptomyces-viridochromogenes tu494
    • s-adenosylmethionine hydrolase
    • dna-adenine methyltransferase
    • pesticidal crystal proteins
    • enterocolitica serotype o-3
    • negative escherichia-coli
    • complete genomic sequence
    • beta-glucuronidase gus
    • resistance gene ba

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