Growth-coupled selection of synthetic modules to accelerate cell factory development

Enrico Orsi; Nico J. Claassens; Pablo I. Nikel; Steffen N. Lindner

doi:10.1038/s41467-021-25665-6

Growth-coupled selection of synthetic modules to accelerate cell factory development

Enrico Orsi, Nico J. Claassens, Pablo I. Nikel, Steffen N. Lindner^*

^*Corresponding author for this work

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Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

39 Citations (Scopus)

Abstract

Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

Original language	English
Article number	5295
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-25665-6
Publication status	Published - Dec 2021

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title = "Growth-coupled selection of synthetic modules to accelerate cell factory development",

abstract = "Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories{\textquoteright} biochemistry for rational bioproduction.",

author = "Enrico Orsi and Claassens, {Nico J.} and Nikel, {Pablo I.} and Lindner, {Steffen N.}",

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AU - Nikel, Pablo I.

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AB - Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

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DO - 10.1038/s41467-021-25665-6

M3 - Comment/Letter to the editor

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SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

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Growth-coupled selection of synthetic modules to accelerate cell factory development

Abstract

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