GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms

J.A. Turkstra, W.M.M. Schaaper, H.B. Oonk, R.H. Meloen

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Gonadotropin releasing hormone (GnRH) occurs in various isoforms in mammals, i.e. GnRH-I (mammalian GnRH), GnRH-II (chicken GnRH-II), GnRH-III (salmon GnRH) and two forms of lamprey GnRH. The function of the latter four molecules have only been partially investigated. Also not much is known about the physiological effects of GnRH-I immunization on the function of these GnRH isoforms. In order to avoid possible harmful side-effects due to undesired neutralization of GnRH isoforms, GnRH-I specificity of antibodies raised against a panel of alternative GnRH antigens was determined. The results show that GnRH antigens can be designed which generate antibodies that specifically bind GnRH-I, without cross-reacting with other GnRH isoforms.
Original languageEnglish
Pages (from-to)4915-4920
JournalVaccine
Volume23
Issue number41
DOIs
Publication statusPublished - 2005

Keywords

  • gonadotropin-releasing-hormone
  • follicle-stimulating-hormone
  • active immunization
  • luteinizing-hormone
  • breast-cancer
  • 2nd isoform
  • brain
  • secretion
  • growth
  • form

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