Gnotobiology and the Study of Complex Interactions between the Intestinal Microbiota, Probiotics, and the Host

Helena Tlaskalova-Hogenova*, Miloslav Kverka, E.F. Verdu, J.M. Wells

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Gnotobiology technology for the breeding of experimental mice originated in the first half of the twentieth century. Earlier studies conducted in germ-free animals revealed the importance of the microbiota in the development of the immune system, gut morphology, and metabolism. These seminal studies have been confirmed and complemented by recent work that exploits the use of modern gnotobiotic technology as well as the combination of high-throughput molecular techniques to study the composition and metabolic capacity of the intestinal microbiota. From a historical perspective, this chapter discusses the evolution of theory concerning complex host-microbiota interactions and probiotics species. It also reviews the current evidence for a role of maladaptive interactions in the development of disease within and beyond the gastrointestinal tract.

Original languageEnglish
Title of host publicationMucosal Immunology: Fourth Edition
PublisherElsevier
Pages109-133
Volume1-2
ISBN (Print)9780124159754, 9780124158474
DOIs
Publication statusPublished - 2015

Keywords

  • Animal models
  • Dysbiosis
  • Germ-free
  • Gnotobiology
  • Gut
  • Immunomodulation
  • Inflammatory diseases
  • Microbiome

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    Tlaskalova-Hogenova, H., Kverka, M., Verdu, E. F., & Wells, J. M. (2015). Gnotobiology and the Study of Complex Interactions between the Intestinal Microbiota, Probiotics, and the Host. In Mucosal Immunology: Fourth Edition (Vol. 1-2, pp. 109-133). Elsevier. https://doi.org/10.1016/B978-0-12-415847-4.00008-2