Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Rene S. Hendriksen, Patrick Munk, Patrick Njage, Bram Van Bunnik, Luke Mcnally, Oksana Lukjancenko, Timo Röder, David Nieuwenhuijse, Susanne Karlsmose Pedersen, Jette Kjeldgaard, Rolf S. Kaas, Philip Thomas Lanken Conradsen Clausen, Josef Korbinian Vogt, Pimlapas Leekitcharoenphon, Milou G.M. Van De Schans, Tina Zuidema, Ana Maria De Roda Husman, Simon Rasmussen, Bent Petersen, Clara AmidGuy Cochrane, Thomas Sicheritz-ponten, Heike Schmitt, Jorge Raul Matheu Alvarez, Awa Aidara-kane, Sünje J. Pamp, Ole Lund, Tine Hald, Mark Woolhouse, Marion P. Koopmans, Håkan Vigre, Thomas Nordahl Petersen, Frank M. Aarestrup*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use meta-genomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
Original languageEnglish
Article number1124
Number of pages12
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 8 Mar 2019

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    Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

    Hendriksen, R. S. (Creator), Munk, P. (Creator), Njage, P. (Creator), van Bunnik, B. (Creator), Mcnally, L. (Creator), Lukjancenko, O. (Creator), Röder, T. (Creator), Nieuwenhuijse, D. (Creator), Pedersen, S. K. (Creator), Kjeldgaard, J. (Creator), van de Schans, M. (Creator), Zuidema, T. (Creator) & Aarestrup, F. M. (Creator), 31 Jan 2019

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    Hendriksen, R. S., Munk, P., Njage, P., Van Bunnik, B., Mcnally, L., Lukjancenko, O., Röder, T., Nieuwenhuijse, D., Pedersen, S. K., Kjeldgaard, J., Kaas, R. S., Clausen, P. T. L. C., Vogt, J. K., Leekitcharoenphon, P., Van De Schans, M. G. M., Zuidema, T., De Roda Husman, A. M., Rasmussen, S., Petersen, B., ... Aarestrup, F. M. (2019). Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature Communications, 10(1), [1124]. https://doi.org/10.1038/s41467-019-08853-3