Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox

Tjerk J. Sminia, Han Zuilhof, Tom Wennekes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.

Original languageEnglish
Pages (from-to)121-141
JournalCarbohydrate Research : an international journal
Volume435
DOIs
Publication statusPublished - 2016

Keywords

  • Bio-orthogonal reactions
  • Chemical probes
  • Glycans
  • Glycobiology
  • Metabolic oligosaccharide engineering

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