Genomics spurs rapid advances in our understanding of the biology of vascular wilt pathogens in the genus Verticillium

A. Klimes, K.F. Dobinson, B. Thomma, S.J. Klosterman

Research output: Contribution to journalReview articleAcademicpeer-review

36 Citations (Scopus)

Abstract

The availability of genomic sequences of several Verticillium species triggered an explosion of genome-scale investigations of mechanisms fundamental to the Verticillium life cycle and disease process. Comparative genomics studies have revealed evolutionary mechanisms, such as hybridization and interchromosomal rearrangements, that have shaped these genomes. Functional analyses of a diverse group of genes encoding virulence factors indicate that successful host xylem colonization relies on specific Verticillium responses to various stresses, including nutrient deficiency and host defense–derived oxidative stress. Regulatory pathways that control responses to changes in nutrient availability also appear to positively control resting structure development. Conversely, resting structure development seems to be repressed by pathways, such as those involving effector secretion, which promote responses to host defenses. The genomics-enabled functional characterization of responses to the challenges presented by the xylem environment, accompanied by identification of novel virulence factors, has rapidly expanded our understanding of niche adaptation in Verticillium species.
LanguageEnglish
Pages181-198
JournalAnnual Review of Phytopathology
Volume53
DOIs
Publication statusPublished - 2015

Fingerprint

vascular wilt
Verticillium
genomics
Biological Sciences
pathogens
xylem
virulence
genome
explosions
nutrient deficiencies
nutrient availability
life cycle (organisms)
stress response
niches
oxidative stress
hybridization
secretion
genes

Keywords

  • protein-kinase gene
  • molecular characterization
  • functional-analysis
  • microsclerotia development
  • ethylene perception
  • hydrophobin gene
  • dahliae kleb
  • tomato ve1
  • resistance
  • expression

Cite this

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title = "Genomics spurs rapid advances in our understanding of the biology of vascular wilt pathogens in the genus Verticillium",
abstract = "The availability of genomic sequences of several Verticillium species triggered an explosion of genome-scale investigations of mechanisms fundamental to the Verticillium life cycle and disease process. Comparative genomics studies have revealed evolutionary mechanisms, such as hybridization and interchromosomal rearrangements, that have shaped these genomes. Functional analyses of a diverse group of genes encoding virulence factors indicate that successful host xylem colonization relies on specific Verticillium responses to various stresses, including nutrient deficiency and host defense–derived oxidative stress. Regulatory pathways that control responses to changes in nutrient availability also appear to positively control resting structure development. Conversely, resting structure development seems to be repressed by pathways, such as those involving effector secretion, which promote responses to host defenses. The genomics-enabled functional characterization of responses to the challenges presented by the xylem environment, accompanied by identification of novel virulence factors, has rapidly expanded our understanding of niche adaptation in Verticillium species.",
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Genomics spurs rapid advances in our understanding of the biology of vascular wilt pathogens in the genus Verticillium. / Klimes, A.; Dobinson, K.F.; Thomma, B.; Klosterman, S.J.

In: Annual Review of Phytopathology, Vol. 53, 2015, p. 181-198.

Research output: Contribution to journalReview articleAcademicpeer-review

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AU - Klimes, A.

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AU - Thomma, B.

AU - Klosterman, S.J.

PY - 2015

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AB - The availability of genomic sequences of several Verticillium species triggered an explosion of genome-scale investigations of mechanisms fundamental to the Verticillium life cycle and disease process. Comparative genomics studies have revealed evolutionary mechanisms, such as hybridization and interchromosomal rearrangements, that have shaped these genomes. Functional analyses of a diverse group of genes encoding virulence factors indicate that successful host xylem colonization relies on specific Verticillium responses to various stresses, including nutrient deficiency and host defense–derived oxidative stress. Regulatory pathways that control responses to changes in nutrient availability also appear to positively control resting structure development. Conversely, resting structure development seems to be repressed by pathways, such as those involving effector secretion, which promote responses to host defenses. The genomics-enabled functional characterization of responses to the challenges presented by the xylem environment, accompanied by identification of novel virulence factors, has rapidly expanded our understanding of niche adaptation in Verticillium species.

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KW - ethylene perception

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KW - resistance

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