Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig

M. van Son; M.F.L. Derks; M.S. Lopes; C.A. Sevillano; B. Harlizius; E. Grindflek

doi:10.3920/978-90-8686-940-4_783

Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig

M. van Son, M.F.L. Derks, M.S. Lopes, C.A. Sevillano, B. Harlizius, E. Grindflek

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

Abstract

The aim of this study was to perform genome-wide association analyses for backfat thickness and osteochondrosis in Landrace pigs and to fine map pleiotropic genomic regions. In order to characterise genomic regions, phenotypic information of 5,000 animals with osteochondrosis scored from CT images and 40,000 animals with backfat thickness scored from CT or ultrasound images were analysed. All animals were genotyped with a medium density SNP chip and a subset of them were genotyped with a high-density SNP chip as well, allowing for imputation. Two genomic loci were found in common for osteochondrosis and backfat thickness, one on chromosome 5 and one on chromosome 14. For both regions, an antagonistic relationship was found. Fine mapping using an impact score approach identified the CCND2 gene as the most likely causal gene on chromosome 5, whereas a mutation in CRTAC1 had the highest impact score in the chromosome 14 region.

Original language	English
Title of host publication	Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publication	Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
Editors	R.F. Veerkamp, Y. de Haas
Place of Publication	Wageningen
Publisher	Wageningen Academic Publishers
Pages	3225-3228
ISBN (Electronic)	9789086869404
DOIs	https://doi.org/10.3920/978-90-8686-940-4_783
Publication status	Published - 2022
Event	World Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands Duration: 3 Jul 2022 → 8 Jul 2022

Conference

Conference	World Congress on Genetics Applied to Livestock Production: WCGALP 2022
Country/Territory	Netherlands
City	Rotterdam
Period	3/07/22 → 8/07/22

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10.3920/978-90-8686-940-4_783Licence: CC BY

https://edepot.wur.nl/588181Licence: CC BY

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van Son, M., Derks, M. F. L., Lopes, M. S., Sevillano, C. A., Harlizius, B., & Grindflek, E. (2022). Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig. In R. F. Veerkamp, & Y. de Haas (Eds.), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges (pp. 3225-3228). Article 783 Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-940-4_783

van Son, M. ; Derks, M.F.L. ; Lopes, M.S. et al. / Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig. Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. editor / R.F. Veerkamp ; Y. de Haas. Wageningen : Wageningen Academic Publishers, 2022. pp. 3225-3228

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title = "Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig",

abstract = "The aim of this study was to perform genome-wide association analyses for backfat thickness and osteochondrosis in Landrace pigs and to fine map pleiotropic genomic regions. In order to characterise genomic regions, phenotypic information of 5,000 animals with osteochondrosis scored from CT images and 40,000 animals with backfat thickness scored from CT or ultrasound images were analysed. All animals were genotyped with a medium density SNP chip and a subset of them were genotyped with a high-density SNP chip as well, allowing for imputation. Two genomic loci were found in common for osteochondrosis and backfat thickness, one on chromosome 5 and one on chromosome 14. For both regions, an antagonistic relationship was found. Fine mapping using an impact score approach identified the CCND2 gene as the most likely causal gene on chromosome 5, whereas a mutation in CRTAC1 had the highest impact score in the chromosome 14 region.",

author = "{van Son}, M. and M.F.L. Derks and M.S. Lopes and C.A. Sevillano and B. Harlizius and E. Grindflek",

year = "2022",

doi = "10.3920/978-90-8686-940-4_783",

language = "English",

pages = "3225--3228",

editor = "R.F. Veerkamp and {de Haas}, Y.",

booktitle = "Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)",

publisher = "Wageningen Academic Publishers",

address = "Netherlands",

note = "World Congress on Genetics Applied to Livestock Production: WCGALP 2022 ; Conference date: 03-07-2022 Through 08-07-2022",

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van Son, M, Derks, MFL, Lopes, MS, Sevillano, CA, Harlizius, B & Grindflek, E 2022, Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig. in RF Veerkamp & Y de Haas (eds), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges., 783, Wageningen Academic Publishers, Wageningen, pp. 3225-3228, World Congress on Genetics Applied to Livestock Production: WCGALP 2022, Rotterdam, Netherlands, 3/07/22. https://doi.org/10.3920/978-90-8686-940-4_783

Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig. / van Son, M.; Derks, M.F.L.; Lopes, M.S. et al.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. ed. / R.F. Veerkamp; Y. de Haas. Wageningen: Wageningen Academic Publishers, 2022. p. 3225-3228 783.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

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T1 - Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig

AU - van Son, M.

AU - Derks, M.F.L.

AU - Lopes, M.S.

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AU - Harlizius, B.

AU - Grindflek, E.

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AB - The aim of this study was to perform genome-wide association analyses for backfat thickness and osteochondrosis in Landrace pigs and to fine map pleiotropic genomic regions. In order to characterise genomic regions, phenotypic information of 5,000 animals with osteochondrosis scored from CT images and 40,000 animals with backfat thickness scored from CT or ultrasound images were analysed. All animals were genotyped with a medium density SNP chip and a subset of them were genotyped with a high-density SNP chip as well, allowing for imputation. Two genomic loci were found in common for osteochondrosis and backfat thickness, one on chromosome 5 and one on chromosome 14. For both regions, an antagonistic relationship was found. Fine mapping using an impact score approach identified the CCND2 gene as the most likely causal gene on chromosome 5, whereas a mutation in CRTAC1 had the highest impact score in the chromosome 14 region.

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BT - Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)

A2 - Veerkamp, R.F.

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PB - Wageningen Academic Publishers

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T2 - World Congress on Genetics Applied to Livestock Production: WCGALP 2022

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ER -

van Son M, Derks MFL, Lopes MS, Sevillano CA, Harlizius B, Grindflek E. Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig. In Veerkamp RF, de Haas Y, editors, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers. 2022. p. 3225-3228. 783 doi: 10.3920/978-90-8686-940-4_783

Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig

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