Genomic regions associated with backfat thickness show pleiotropic effect on osteochondrosis in pig

M. van Son, M.F.L. Derks, M.S. Lopes, C.A. Sevillano, B. Harlizius, E. Grindflek

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

Abstract

The aim of this study was to perform genome-wide association analyses for backfat thickness and osteochondrosis in Landrace pigs and to fine map pleiotropic genomic regions. In order to characterise genomic regions, phenotypic information of 5,000 animals with osteochondrosis scored from CT images and 40,000 animals with backfat thickness scored from CT or ultrasound images were analysed. All animals were genotyped with a medium density SNP chip and a subset of them were genotyped with a high-density SNP chip as well, allowing for imputation. Two genomic loci were found in common for osteochondrosis and backfat thickness, one on chromosome 5 and one on chromosome 14. For both regions, an antagonistic relationship was found. Fine mapping using an impact score approach identified the CCND2 gene as the most likely causal gene on chromosome 5, whereas a mutation in CRTAC1 had the highest impact score in the chromosome 14 region.
Original languageEnglish
Title of host publicationProceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publicationTechnical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
EditorsR.F. Veerkamp, Y. de Haas
Place of PublicationWageningen
PublisherWageningen Academic Publishers
Pages3225-3228
ISBN (Electronic)9789086869404
DOIs
Publication statusPublished - 2022
EventWorld Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands
Duration: 3 Jul 20228 Jul 2022

Conference

ConferenceWorld Congress on Genetics Applied to Livestock Production: WCGALP 2022
Country/TerritoryNetherlands
CityRotterdam
Period3/07/228/07/22

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