Genome-wide scan for body composition in pigs reveals important role of imprinting

D.J. de Koning, A.P. Rattink, B. Harlizius, J.A.M. van Arendonk, E.W. Brascamp, M.A.M. Groenen

Research output: Contribution to journalArticleAcademicpeer-review

221 Citations (Scopus)

Abstract

The role of imprinting in body composition was investigated in an experimental cross between Chinese Meishan pigs and commercial Dutch pigs. A whole-genome scan revealed significant evidence for five quantitative trait loci (QTL) affecting body composition, of which four were imprinted. Imprinting was tested with a statistical model that separated the expression of paternally and maternally inherited alleles. For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7. In the same region of SSC7, a maternally expressed QTL affecting muscle depth was found. Chromosome 6 harbored a maternally expressed QTL on the short arm and a paternally expressed QTL on the long arm, both affecting intramuscular fat content. The individual QTL explained from 2 p to 10 f the phenotypic variance. The known homologies to human and mouse did not reveal positional candidate genes. This study demonstrates that testing for imprinting should become a standard procedure to unravel the genetic control of multifactorial traits.
Original languageEnglish
Pages (from-to)7947-7950
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number14
DOIs
Publication statusPublished - 2000

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