Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians

Grum Gebreyesus, Bart Buitenhuis, Nina A. Poulsen, M.H.P.W. Visker, Qianqian Zhang, H.J.F. van Valenberg, D. Sun, H. Bovenhuis

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

Data for the de novo synthesized milk fatty acids (FAs) were obtained from milk samples of 1736 Dutch, 675 Danish and 784 Chinese Holstein Friesian cows and combined for multipopulation genome-wide association study (GWAS) using a mixed linear model. Results were compared with population specific GWAS undertaken for each population. In the combined analysis, QTL regions spread across 16 chromosomes were found significantly associated with the de novo synthesized FAs. Compared to the population-specific analyses, our multipopulation GWAS resulted in more regions showing significant associations for the de novo synthesized FAs, some of which were not previously reported.
Original languageEnglish
Title of host publicationProceedings of the World Congress on Genetics Applied to Livestock Production
Subtitle of host publicationVolume Biology & Species - Bovine (dairy) 2
PublisherWCGALP
Number of pages6
Publication statusPublished - Feb 2018
Event11th World Congress on Genetics Applied to Livestock Production - Auckland, New Zealand
Duration: 11 Feb 201816 Feb 2018

Conference

Conference11th World Congress on Genetics Applied to Livestock Production
CountryNew Zealand
CityAuckland
Period11/02/1816/02/18

Fingerprint

Holstein
fatty acids
quantitative trait loci
linear models
chromosomes
cows
milk
genome-wide association study
milk fatty acids
sampling

Cite this

Gebreyesus, G., Buitenhuis, B., Poulsen, N. A., Visker, M. H. P. W., Zhang, Q., van Valenberg, H. J. F., ... Bovenhuis, H. (2018). Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians. In Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology & Species - Bovine (dairy) 2 [141] WCGALP.
Gebreyesus, Grum ; Buitenhuis, Bart ; Poulsen, Nina A. ; Visker, M.H.P.W. ; Zhang, Qianqian ; van Valenberg, H.J.F. ; Sun, D. ; Bovenhuis, H. / Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians. Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology & Species - Bovine (dairy) 2. WCGALP, 2018.
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title = "Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians",
abstract = "Data for the de novo synthesized milk fatty acids (FAs) were obtained from milk samples of 1736 Dutch, 675 Danish and 784 Chinese Holstein Friesian cows and combined for multipopulation genome-wide association study (GWAS) using a mixed linear model. Results were compared with population specific GWAS undertaken for each population. In the combined analysis, QTL regions spread across 16 chromosomes were found significantly associated with the de novo synthesized FAs. Compared to the population-specific analyses, our multipopulation GWAS resulted in more regions showing significant associations for the de novo synthesized FAs, some of which were not previously reported.",
author = "Grum Gebreyesus and Bart Buitenhuis and Poulsen, {Nina A.} and M.H.P.W. Visker and Qianqian Zhang and {van Valenberg}, H.J.F. and D. Sun and H. Bovenhuis",
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Gebreyesus, G, Buitenhuis, B, Poulsen, NA, Visker, MHPW, Zhang, Q, van Valenberg, HJF, Sun, D & Bovenhuis, H 2018, Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians. in Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology & Species - Bovine (dairy) 2., 141, WCGALP, 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11/02/18.

Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians. / Gebreyesus, Grum; Buitenhuis, Bart; Poulsen, Nina A.; Visker, M.H.P.W.; Zhang, Qianqian; van Valenberg, H.J.F.; Sun, D.; Bovenhuis, H.

Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology & Species - Bovine (dairy) 2. WCGALP, 2018. 141.

Research output: Chapter in Book/Report/Conference proceedingConference paper

TY - GEN

T1 - Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians

AU - Gebreyesus, Grum

AU - Buitenhuis, Bart

AU - Poulsen, Nina A.

AU - Visker, M.H.P.W.

AU - Zhang, Qianqian

AU - van Valenberg, H.J.F.

AU - Sun, D.

AU - Bovenhuis, H.

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N2 - Data for the de novo synthesized milk fatty acids (FAs) were obtained from milk samples of 1736 Dutch, 675 Danish and 784 Chinese Holstein Friesian cows and combined for multipopulation genome-wide association study (GWAS) using a mixed linear model. Results were compared with population specific GWAS undertaken for each population. In the combined analysis, QTL regions spread across 16 chromosomes were found significantly associated with the de novo synthesized FAs. Compared to the population-specific analyses, our multipopulation GWAS resulted in more regions showing significant associations for the de novo synthesized FAs, some of which were not previously reported.

AB - Data for the de novo synthesized milk fatty acids (FAs) were obtained from milk samples of 1736 Dutch, 675 Danish and 784 Chinese Holstein Friesian cows and combined for multipopulation genome-wide association study (GWAS) using a mixed linear model. Results were compared with population specific GWAS undertaken for each population. In the combined analysis, QTL regions spread across 16 chromosomes were found significantly associated with the de novo synthesized FAs. Compared to the population-specific analyses, our multipopulation GWAS resulted in more regions showing significant associations for the de novo synthesized FAs, some of which were not previously reported.

M3 - Conference paper

BT - Proceedings of the World Congress on Genetics Applied to Livestock Production

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Gebreyesus G, Buitenhuis B, Poulsen NA, Visker MHPW, Zhang Q, van Valenberg HJF et al. Genome-wide association study of the de novo synthesized milk fatty acids based on Dutch, Danish and Chinese Holstein Friesians. In Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology & Species - Bovine (dairy) 2. WCGALP. 2018. 141