Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N. Orr; E.W. Hill; G. Gu; P. Govindarajan; J. Conroy; E.M. van Grevenhof; B.J. Ducro; J.A.M. van Arendonk; J.H. Knaap; P.R. van Weeren; D.E. Machugh; S. Ennis; P.A. Brama

doi:10.1111/age.12016

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N. Orr
, E.W. Hill
, G. Gu
, P. Govindarajan
, J. Conroy
, E.M. van Grevenhof
, B.J. Ducro
, J.A.M. van Arendonk
, J.H. Knaap
, P.R. van Weeren
, D.E. Machugh
, S. Ennis
, P.A. Brama

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10-7) and chromosome 10 (BIEC2-121323; P = 2.62 × 10-7).

Original language	English
Pages (from-to)	408-412
Journal	Animal Genetics
Volume	44
Issue number	4
DOIs	https://doi.org/10.1111/age.12016
Publication status	Published - 2013

Keywords

german coldblood horses
manifestations
prevalence
dissecans
markers
fetlock

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10.1111/age.12016

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Orr, N., Hill, E. W., Gu, G., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A. M., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., & Brama, P. A. (2013). Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. Animal Genetics, 44(4), 408-412. https://doi.org/10.1111/age.12016

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title = "Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10",

abstract = "Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10-7) and chromosome 10 (BIEC2-121323; P = 2.62 × 10-7).",

keywords = "german coldblood horses, manifestations, prevalence, dissecans, markers, fetlock",

author = "N. Orr and E.W. Hill and G. Gu and P. Govindarajan and J. Conroy and \{van Grevenhof\}, E.M. and B.J. Ducro and \{van Arendonk\}, J.A.M. and J.H. Knaap and \{van Weeren\}, P.R. and D.E. Machugh and S. Ennis and P.A. Brama",

year = "2013",

doi = "10.1111/age.12016",

language = "English",

volume = "44",

pages = "408--412",

journal = "Animal Genetics",

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publisher = "Wiley",

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}

Orr, N, Hill, EW, Gu, G, Govindarajan, P, Conroy, J, van Grevenhof, EM, Ducro, BJ, van Arendonk, JAM, Knaap, JH, van Weeren, PR, Machugh, DE, Ennis, S & Brama, PA 2013, 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10', Animal Genetics, vol. 44, no. 4, pp. 408-412. https://doi.org/10.1111/age.12016

TY - JOUR

T1 - Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

AU - Orr, N.

AU - Hill, E.W.

AU - Gu, G.

AU - Govindarajan, P.

AU - Conroy, J.

AU - van Grevenhof, E.M.

AU - Ducro, B.J.

AU - van Arendonk, J.A.M.

AU - Knaap, J.H.

AU - van Weeren, P.R.

AU - Machugh, D.E.

AU - Ennis, S.

AU - Brama, P.A.

PY - 2013

Y1 - 2013

N2 - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10-7) and chromosome 10 (BIEC2-121323; P = 2.62 × 10-7).

AB - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10-7) and chromosome 10 (BIEC2-121323; P = 2.62 × 10-7).

KW - german coldblood horses

KW - manifestations

KW - prevalence

KW - dissecans

KW - markers

KW - fetlock

U2 - 10.1111/age.12016

DO - 10.1111/age.12016

M3 - Article

SN - 0268-9146

VL - 44

SP - 408

EP - 412

JO - Animal Genetics

JF - Animal Genetics

IS - 4

ER -

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

Abstract

Keywords

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