Genome packaging of the Bunyavirales

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

The order Bunyavirales comprises nine families of enveloped, negative-strand RNA viruses. Depending on the family and genus, bunyaviruses (i.e. now referring to all members of the Bunyavirales) contain genomes consisting of two to six segments. Each genome segment is encapsidated by multiple copies of the nucleocapsid (N) protein and one or a few molecules of the viral polymerase, forming so-called ribonucleoproteins (RNPs). Incorporation of RNPs into virions is mediated by the interaction of N with the cytoplasmic tails of the structural glycoproteins. Although some selectivity exists in the packaging of RNPs into virions, which seems to be driven by the 5′ and 3′-untranslated regions of the genomic RNA segments, evidence is accumulating that bunyavirus genome packaging is a stochastic process.

LanguageEnglish
Pages151-155
JournalCurrent Opinion in Virology
Volume33
DOIs
Publication statusPublished - 1 Dec 2018

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Ribonucleoproteins
Product Packaging
Orthobunyavirus
Genome
Virion
Stochastic Processes
Nucleocapsid Proteins
5' Untranslated Regions
RNA Viruses
3' Untranslated Regions
RNA

Cite this

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title = "Genome packaging of the Bunyavirales",
abstract = "The order Bunyavirales comprises nine families of enveloped, negative-strand RNA viruses. Depending on the family and genus, bunyaviruses (i.e. now referring to all members of the Bunyavirales) contain genomes consisting of two to six segments. Each genome segment is encapsidated by multiple copies of the nucleocapsid (N) protein and one or a few molecules of the viral polymerase, forming so-called ribonucleoproteins (RNPs). Incorporation of RNPs into virions is mediated by the interaction of N with the cytoplasmic tails of the structural glycoproteins. Although some selectivity exists in the packaging of RNPs into virions, which seems to be driven by the 5′ and 3′-untranslated regions of the genomic RNA segments, evidence is accumulating that bunyavirus genome packaging is a stochastic process.",
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Genome packaging of the Bunyavirales. / Wichgers Schreur, Paul J.; Kormelink, Richard; Kortekaas, Jeroen.

In: Current Opinion in Virology, Vol. 33, 01.12.2018, p. 151-155.

Research output: Contribution to journalReview articleAcademicpeer-review

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