Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

Abigail L. Lind, Yvonne Y.Y. Lai, Yulia Mostovoy, Alisha K. Holloway, Alessio Iannucci, Angel C.Y. Mak, Marco Fondi, Valerio Orlandini, Walter L. Eckalbar, Massimo Milan, Michail Rovatsos, Ilya G. Kichigin, Alex I. Makunin, Martina Johnson Pokorná, Marie Altmanová, Vladimir A. Trifonov, Elio Schijlen, Lukáš Kratochvíl, Renato Fani, Petr Velenský & 10 others Ivan Rehák, Tomaso Patarnello, Tim S. Jessop, James W. Hicks, Oliver A. Ryder, Joseph R. Mendelson, Claudio Ciofi, Pui Yan Kwok, Katherine S. Pollard, Benoit G. Bruneau

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

LanguageEnglish
Pages1241-1252
JournalNature Ecology and Evolution
Volume3
Issue number8
DOIs
Publication statusPublished - 29 Jul 2019

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lizard
lizards
genome
reptile
anticoagulant
sensory system
kairomone
cardiovascular system
saliva
hemostasis
gene
homeostasis
pheromone
reptiles
physiology
chromosome
mammal
metabolism
anticoagulant activity
genome assembly

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Lind, A. L., Lai, Y. Y. Y., Mostovoy, Y., Holloway, A. K., Iannucci, A., Mak, A. C. Y., ... Bruneau, B. G. (2019). Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards. Nature Ecology and Evolution, 3(8), 1241-1252. https://doi.org/10.1038/s41559-019-0945-8
Lind, Abigail L. ; Lai, Yvonne Y.Y. ; Mostovoy, Yulia ; Holloway, Alisha K. ; Iannucci, Alessio ; Mak, Angel C.Y. ; Fondi, Marco ; Orlandini, Valerio ; Eckalbar, Walter L. ; Milan, Massimo ; Rovatsos, Michail ; Kichigin, Ilya G. ; Makunin, Alex I. ; Johnson Pokorná, Martina ; Altmanová, Marie ; Trifonov, Vladimir A. ; Schijlen, Elio ; Kratochvíl, Lukáš ; Fani, Renato ; Velenský, Petr ; Rehák, Ivan ; Patarnello, Tomaso ; Jessop, Tim S. ; Hicks, James W. ; Ryder, Oliver A. ; Mendelson, Joseph R. ; Ciofi, Claudio ; Kwok, Pui Yan ; Pollard, Katherine S. ; Bruneau, Benoit G. / Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards. In: Nature Ecology and Evolution. 2019 ; Vol. 3, No. 8. pp. 1241-1252.
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title = "Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards",
abstract = "Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.",
author = "Lind, {Abigail L.} and Lai, {Yvonne Y.Y.} and Yulia Mostovoy and Holloway, {Alisha K.} and Alessio Iannucci and Mak, {Angel C.Y.} and Marco Fondi and Valerio Orlandini and Eckalbar, {Walter L.} and Massimo Milan and Michail Rovatsos and Kichigin, {Ilya G.} and Makunin, {Alex I.} and {Johnson Pokorn{\'a}}, Martina and Marie Altmanov{\'a} and Trifonov, {Vladimir A.} and Elio Schijlen and Luk{\'a}š Kratochv{\'i}l and Renato Fani and Petr Velensk{\'y} and Ivan Reh{\'a}k and Tomaso Patarnello and Jessop, {Tim S.} and Hicks, {James W.} and Ryder, {Oliver A.} and Mendelson, {Joseph R.} and Claudio Ciofi and Kwok, {Pui Yan} and Pollard, {Katherine S.} and Bruneau, {Benoit G.}",
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Lind, AL, Lai, YYY, Mostovoy, Y, Holloway, AK, Iannucci, A, Mak, ACY, Fondi, M, Orlandini, V, Eckalbar, WL, Milan, M, Rovatsos, M, Kichigin, IG, Makunin, AI, Johnson Pokorná, M, Altmanová, M, Trifonov, VA, Schijlen, E, Kratochvíl, L, Fani, R, Velenský, P, Rehák, I, Patarnello, T, Jessop, TS, Hicks, JW, Ryder, OA, Mendelson, JR, Ciofi, C, Kwok, PY, Pollard, KS & Bruneau, BG 2019, 'Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards', Nature Ecology and Evolution, vol. 3, no. 8, pp. 1241-1252. https://doi.org/10.1038/s41559-019-0945-8

Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards. / Lind, Abigail L.; Lai, Yvonne Y.Y.; Mostovoy, Yulia; Holloway, Alisha K.; Iannucci, Alessio; Mak, Angel C.Y.; Fondi, Marco; Orlandini, Valerio; Eckalbar, Walter L.; Milan, Massimo; Rovatsos, Michail; Kichigin, Ilya G.; Makunin, Alex I.; Johnson Pokorná, Martina; Altmanová, Marie; Trifonov, Vladimir A.; Schijlen, Elio; Kratochvíl, Lukáš; Fani, Renato; Velenský, Petr; Rehák, Ivan; Patarnello, Tomaso; Jessop, Tim S.; Hicks, James W.; Ryder, Oliver A.; Mendelson, Joseph R.; Ciofi, Claudio; Kwok, Pui Yan; Pollard, Katherine S.; Bruneau, Benoit G.

In: Nature Ecology and Evolution, Vol. 3, No. 8, 29.07.2019, p. 1241-1252.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

AU - Lind, Abigail L.

AU - Lai, Yvonne Y.Y.

AU - Mostovoy, Yulia

AU - Holloway, Alisha K.

AU - Iannucci, Alessio

AU - Mak, Angel C.Y.

AU - Fondi, Marco

AU - Orlandini, Valerio

AU - Eckalbar, Walter L.

AU - Milan, Massimo

AU - Rovatsos, Michail

AU - Kichigin, Ilya G.

AU - Makunin, Alex I.

AU - Johnson Pokorná, Martina

AU - Altmanová, Marie

AU - Trifonov, Vladimir A.

AU - Schijlen, Elio

AU - Kratochvíl, Lukáš

AU - Fani, Renato

AU - Velenský, Petr

AU - Rehák, Ivan

AU - Patarnello, Tomaso

AU - Jessop, Tim S.

AU - Hicks, James W.

AU - Ryder, Oliver A.

AU - Mendelson, Joseph R.

AU - Ciofi, Claudio

AU - Kwok, Pui Yan

AU - Pollard, Katherine S.

AU - Bruneau, Benoit G.

PY - 2019/7/29

Y1 - 2019/7/29

N2 - Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

AB - Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

U2 - 10.1038/s41559-019-0945-8

DO - 10.1038/s41559-019-0945-8

M3 - Article

VL - 3

SP - 1241

EP - 1252

JO - Nature Ecology & Evolution

T2 - Nature Ecology & Evolution

JF - Nature Ecology & Evolution

SN - 2397-334X

IS - 8

ER -