Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

S.W. van den Berg; M.E.T. Dolle; S. Imholz; D.L. van der A; R. van 't Slot; C. Wijmenga; W.M.M. Verschuren; C. Strien; C.L.E. Siezen; B. Hoebee; E.J.M. Feskens; J.M.A. Boer

doi:10.1038/ijo.2009.152

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

S.W. van den Berg, M.E.T. Dolle, S. Imholz, D.L. van der A, R. van 't Slot, C. Wijmenga, W.M.M. Verschuren, C. Strien, C.L.E. Siezen, B. Hoebee, E.J.M. Feskens, J.M.A. Boer

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Abstract

Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity. Objective: To explore associations between single nucleotide polymorphisms ( SNPs) in candidate genes from regulatory pathways that control fatty acid and glucose metabolism, and repeated measurements of body mass index (BMI) and waist circumference in a large Dutch study population. Methods: Data of 327 SNPs across 239 genes were analyzed for 3575 participants of the Doetinchem cohort, who were examined three times during 11 years, using the Illumina Golden Gate assay. Adjusted random coefficient models were used to analyze the relationship between SNPS and obesity phenotypes. False discovery rate q-values were calculated to account for multiple testing. Significance of the associations was defined as a q-value

Original language	English
Pages (from-to)	1143-1152
Journal	International Journal of Obesity
Volume	33
Issue number	10
DOIs	https://doi.org/10.1038/ijo.2009.152
Publication status	Published - 2009

Keywords

genome-wide association
activated receptor-gamma
body-mass index
transcriptional regulation
postmenopausal women
waist circumference
apolipoprotein-e
polymorphisms
weight
metaanalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2009.152

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van den Berg, S. W., Dolle, M. E. T., Imholz, S., van der A, D. L., van 't Slot, R., Wijmenga, C., Verschuren, W. M. M., Strien, C., Siezen, C. L. E., Hoebee, B., Feskens, E. J. M., & Boer, J. M. A. (2009). Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. International Journal of Obesity, 33(10), 1143-1152. https://doi.org/10.1038/ijo.2009.152

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title = "Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study",

abstract = "Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity. Objective: To explore associations between single nucleotide polymorphisms ( SNPs) in candidate genes from regulatory pathways that control fatty acid and glucose metabolism, and repeated measurements of body mass index (BMI) and waist circumference in a large Dutch study population. Methods: Data of 327 SNPs across 239 genes were analyzed for 3575 participants of the Doetinchem cohort, who were examined three times during 11 years, using the Illumina Golden Gate assay. Adjusted random coefficient models were used to analyze the relationship between SNPS and obesity phenotypes. False discovery rate q-values were calculated to account for multiple testing. Significance of the associations was defined as a q-value",

keywords = "genome-wide association, activated receptor-gamma, body-mass index, transcriptional regulation, postmenopausal women, waist circumference, apolipoprotein-e, polymorphisms, weight, metaanalysis",

author = "{van den Berg}, S.W. and M.E.T. Dolle and S. Imholz and {van der A}, D.L. and {van 't Slot}, R. and C. Wijmenga and W.M.M. Verschuren and C. Strien and C.L.E. Siezen and B. Hoebee and E.J.M. Feskens and J.M.A. Boer",

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van den Berg, SW, Dolle, MET, Imholz, S, van der A, DL, van 't Slot, R, Wijmenga, C, Verschuren, WMM, Strien, C, Siezen, CLE, Hoebee, B, Feskens, EJM & Boer, JMA 2009, 'Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study', International Journal of Obesity, vol. 33, no. 10, pp. 1143-1152. https://doi.org/10.1038/ijo.2009.152

TY - JOUR

T1 - Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

AU - van den Berg, S.W.

AU - Dolle, M.E.T.

AU - Imholz, S.

AU - van der A, D.L.

AU - van 't Slot, R.

AU - Wijmenga, C.

AU - Verschuren, W.M.M.

AU - Strien, C.

AU - Siezen, C.L.E.

AU - Hoebee, B.

AU - Feskens, E.J.M.

AU - Boer, J.M.A.

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PY - 2009

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N2 - Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity. Objective: To explore associations between single nucleotide polymorphisms ( SNPs) in candidate genes from regulatory pathways that control fatty acid and glucose metabolism, and repeated measurements of body mass index (BMI) and waist circumference in a large Dutch study population. Methods: Data of 327 SNPs across 239 genes were analyzed for 3575 participants of the Doetinchem cohort, who were examined three times during 11 years, using the Illumina Golden Gate assay. Adjusted random coefficient models were used to analyze the relationship between SNPS and obesity phenotypes. False discovery rate q-values were calculated to account for multiple testing. Significance of the associations was defined as a q-value

AB - Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity. Objective: To explore associations between single nucleotide polymorphisms ( SNPs) in candidate genes from regulatory pathways that control fatty acid and glucose metabolism, and repeated measurements of body mass index (BMI) and waist circumference in a large Dutch study population. Methods: Data of 327 SNPs across 239 genes were analyzed for 3575 participants of the Doetinchem cohort, who were examined three times during 11 years, using the Illumina Golden Gate assay. Adjusted random coefficient models were used to analyze the relationship between SNPS and obesity phenotypes. False discovery rate q-values were calculated to account for multiple testing. Significance of the associations was defined as a q-value

KW - genome-wide association

KW - activated receptor-gamma

KW - body-mass index

KW - transcriptional regulation

KW - postmenopausal women

KW - waist circumference

KW - apolipoprotein-e

KW - polymorphisms

KW - weight

KW - metaanalysis

U2 - 10.1038/ijo.2009.152

DO - 10.1038/ijo.2009.152

M3 - Article

SN - 0307-0565

VL - 33

SP - 1143

EP - 1152

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 10

ER -

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

Abstract

Keywords

UN SDGs

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