Genetic variation in paratuberculosis in dairy populations

K.J.E. van Hulzen, J.A.M. van Arendonk, H.C.M. Heuven

Research output: Thesispromoter, other

Abstract

Paratuberculosis, also known as Johne’s disease, is caused by oral uptake of Mycobacterium avium subspecies paratuberculosis (MAP) from the environment. MAP causes granulomatous lesions in the distal part of the ileum in domestic and wild ruminants.Ileal lesions limit sufficient nutrient uptake leading to weight loss and additionally, in animals used for dairy production, infection with paratuberculosis leads to decreased milk production and fertility. In the Dutch Holstein-Friesian dairy cattle population, prevalence of paratuberculosis based on a positive ELISA test in milk was 46.7% on the herd level and 2.4% on the animal level in 2008. Prevalence of paratuberculosis in dairy goat herds is unknown but suspected to be higher than in cattle herds based on clinical and routine pathological observations.The aim of this thesis is to contribute to control of paratuberculosis by investigating genetic variation in the pathogen and studying genetic variation in host susceptibility. Genetic variation of the pathogen was investigated within and between herds in the Netherlands. For host susceptibility to paratuberculosis, genetic variation and heritability were estimated for dairy cattle and dairy goats. For dairy cattle, results from the quantitative genetic analysis were used to perform a genome-wide association study to find chromosomal regions associated with susceptibility to disease. Finally, a genetic-epidemiological model was used to study the effect of genetic selection for increased resistance to paratuberculosis on the prevalence of infection in the dairy cattle population.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Utrecht University
Supervisors/Advisors
  • van Arendonk, Johan, Promotor
  • Nielen, M., Promotor
  • Koets, A.P., Co-promotor, External person
  • Heuven, Henri, Co-promotor
Award date6 Dec 2012
Place of PublicationEde
Publisher
Print ISBNs9789039358733
Publication statusPublished - 2012

Fingerprint

paratuberculosis
dairies
genetic variation
dairy cattle
herds
Mycobacterium avium
dairy goats
lesions (animal)
milk production
milk analysis
pathogens
quantitative genetics
ileum
infection
nutrient uptake
genetic techniques and protocols
mouth
ruminants
Netherlands
animals

Cite this

van Hulzen, K. J. E., van Arendonk, J. A. M., & Heuven, H. C. M. (2012). Genetic variation in paratuberculosis in dairy populations. Ede: s.n.
van Hulzen, K.J.E. ; van Arendonk, J.A.M. ; Heuven, H.C.M.. / Genetic variation in paratuberculosis in dairy populations. Ede : s.n., 2012. 135 p.
@phdthesis{316da175881b46efbb811e58e601ed2a,
title = "Genetic variation in paratuberculosis in dairy populations",
abstract = "Paratuberculosis, also known as Johne’s disease, is caused by oral uptake of Mycobacterium avium subspecies paratuberculosis (MAP) from the environment. MAP causes granulomatous lesions in the distal part of the ileum in domestic and wild ruminants.Ileal lesions limit sufficient nutrient uptake leading to weight loss and additionally, in animals used for dairy production, infection with paratuberculosis leads to decreased milk production and fertility. In the Dutch Holstein-Friesian dairy cattle population, prevalence of paratuberculosis based on a positive ELISA test in milk was 46.7{\%} on the herd level and 2.4{\%} on the animal level in 2008. Prevalence of paratuberculosis in dairy goat herds is unknown but suspected to be higher than in cattle herds based on clinical and routine pathological observations.The aim of this thesis is to contribute to control of paratuberculosis by investigating genetic variation in the pathogen and studying genetic variation in host susceptibility. Genetic variation of the pathogen was investigated within and between herds in the Netherlands. For host susceptibility to paratuberculosis, genetic variation and heritability were estimated for dairy cattle and dairy goats. For dairy cattle, results from the quantitative genetic analysis were used to perform a genome-wide association study to find chromosomal regions associated with susceptibility to disease. Finally, a genetic-epidemiological model was used to study the effect of genetic selection for increased resistance to paratuberculosis on the prevalence of infection in the dairy cattle population.",
author = "{van Hulzen}, K.J.E. and {van Arendonk}, J.A.M. and H.C.M. Heuven",
note = "Volledige thesis tekst openbaar vanaf 6-6-2013 (volgens website UU)",
year = "2012",
language = "English",
isbn = "9789039358733",
publisher = "s.n.",
school = "Utrecht University",

}

van Hulzen, KJE, van Arendonk, JAM & Heuven, HCM 2012, 'Genetic variation in paratuberculosis in dairy populations', Doctor of Philosophy, Utrecht University, Ede.

Genetic variation in paratuberculosis in dairy populations. / van Hulzen, K.J.E.; van Arendonk, J.A.M.; Heuven, H.C.M.

Ede : s.n., 2012. 135 p.

Research output: Thesispromoter, other

TY - THES

T1 - Genetic variation in paratuberculosis in dairy populations

AU - van Hulzen, K.J.E.

AU - van Arendonk, J.A.M.

AU - Heuven, H.C.M.

N1 - Volledige thesis tekst openbaar vanaf 6-6-2013 (volgens website UU)

PY - 2012

Y1 - 2012

N2 - Paratuberculosis, also known as Johne’s disease, is caused by oral uptake of Mycobacterium avium subspecies paratuberculosis (MAP) from the environment. MAP causes granulomatous lesions in the distal part of the ileum in domestic and wild ruminants.Ileal lesions limit sufficient nutrient uptake leading to weight loss and additionally, in animals used for dairy production, infection with paratuberculosis leads to decreased milk production and fertility. In the Dutch Holstein-Friesian dairy cattle population, prevalence of paratuberculosis based on a positive ELISA test in milk was 46.7% on the herd level and 2.4% on the animal level in 2008. Prevalence of paratuberculosis in dairy goat herds is unknown but suspected to be higher than in cattle herds based on clinical and routine pathological observations.The aim of this thesis is to contribute to control of paratuberculosis by investigating genetic variation in the pathogen and studying genetic variation in host susceptibility. Genetic variation of the pathogen was investigated within and between herds in the Netherlands. For host susceptibility to paratuberculosis, genetic variation and heritability were estimated for dairy cattle and dairy goats. For dairy cattle, results from the quantitative genetic analysis were used to perform a genome-wide association study to find chromosomal regions associated with susceptibility to disease. Finally, a genetic-epidemiological model was used to study the effect of genetic selection for increased resistance to paratuberculosis on the prevalence of infection in the dairy cattle population.

AB - Paratuberculosis, also known as Johne’s disease, is caused by oral uptake of Mycobacterium avium subspecies paratuberculosis (MAP) from the environment. MAP causes granulomatous lesions in the distal part of the ileum in domestic and wild ruminants.Ileal lesions limit sufficient nutrient uptake leading to weight loss and additionally, in animals used for dairy production, infection with paratuberculosis leads to decreased milk production and fertility. In the Dutch Holstein-Friesian dairy cattle population, prevalence of paratuberculosis based on a positive ELISA test in milk was 46.7% on the herd level and 2.4% on the animal level in 2008. Prevalence of paratuberculosis in dairy goat herds is unknown but suspected to be higher than in cattle herds based on clinical and routine pathological observations.The aim of this thesis is to contribute to control of paratuberculosis by investigating genetic variation in the pathogen and studying genetic variation in host susceptibility. Genetic variation of the pathogen was investigated within and between herds in the Netherlands. For host susceptibility to paratuberculosis, genetic variation and heritability were estimated for dairy cattle and dairy goats. For dairy cattle, results from the quantitative genetic analysis were used to perform a genome-wide association study to find chromosomal regions associated with susceptibility to disease. Finally, a genetic-epidemiological model was used to study the effect of genetic selection for increased resistance to paratuberculosis on the prevalence of infection in the dairy cattle population.

M3 - promoter, other

SN - 9789039358733

PB - s.n.

CY - Ede

ER -

van Hulzen KJE, van Arendonk JAM, Heuven HCM. Genetic variation in paratuberculosis in dairy populations. Ede: s.n., 2012. 135 p.