Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota

Yuqing Huang, Jan E. Kammenga*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions. View Full-Text
Original languageEnglish
Article number618
JournalMicroorganisms
Volume8
Issue number4
DOIs
Publication statusPublished - 24 Apr 2020

Keywords

  • Caenorhabditis elegans
  • Genetic variation
  • Microbiota

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