Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women

Fuxing Chen, Zheng Zhu, Fränzel J.B. Van Duijnhoven, Meihua Dong, Yun Qian, Hao Yu, Jie Yang, Lan Cui, Renqiang Han, Jian Su, Wencong Du, Jinyi Zhou, Ming Wu*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The group-specific component (GC) gene, one of the vitamin D pathway genes, seems to play an important role in cancer development. A population-based breast cancer study including 818 cases and 935 controls in a Chinese population was carried out to evaluate the potential associations of four polymorphisms (rs16847024, rs17467825, rs2298850, and rs3755967) in the GC gene with risk of breast cancer. We detected three SNPs with statistically significant effects on breast cancer development after adjusting for age, menopausal status, body mass index (BMI), family history of breast cancer, income, waist circumference, and education (rs17467825: adjusted OR = 0.80, 95% CI = 0.65-0.99; rs2298850: adjusted OR = 0.80, 95% CI = 0.65-0.98; rs3755967: adjusted OR = 0.80, 95% CI = 0.65-0.98). Stratified analysis found that when an individual had a waist circumference <80 cm, rs17467825, rs2298850, and rs3755967 could markedly reduce the risk of breast cancer. Significant interactions between polymorphisms of rs2298850 and rs3755967 and waist circumference were also observed for breast cancer risk. Combined analysis revealed a significant association among the allele numbers of protective effects with decreased breast cancer risk (Ptrend=0.043). These results indicated that, in the GC gene, genetic mutations might be related to breast cancer susceptibility in Chinese women.

Original languageEnglish
Article number3295781
JournalBioMed Research International
Volume2019
DOIs
Publication statusPublished - 15 Nov 2019

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    Chen, F., Zhu, Z., Van Duijnhoven, F. J. B., Dong, M., Qian, Y., Yu, H., Yang, J., Cui, L., Han, R., Su, J., Du, W., Zhou, J., & Wu, M. (2019). Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women. BioMed Research International, 2019, [3295781]. https://doi.org/10.1155/2019/3295781