Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm childeren is asosiated with airway remodeling genes and innate immune genes

C.L.E. Siezen, H.M. Hodemaekers, M.J. Ermers, G. Doornbos, R. van 't Slot, I.C. Wijmenga, H.C. Houwelingen, J.L.L. Kimpen, T.G. Kimman, B. Hoebee, R. Janssen

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)

Abstract

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children
Original languageEnglish
Pages (from-to)333-335
JournalThe Pediatric Infectious Disease Journal
Volume28
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • interferon signal-transduction
  • lung-function
  • asthma
  • polymorphisms
  • adam33
  • disease
  • kinase

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